10 - LINKING 1 Flashcards
where do activated DCs go
travel via lymphatic vessel to go to the closest lymph node
activated DCs express receptors that target them to lymphoid tissue
what are the three signals that T cells are activated through
activated by antigen presenting cells (APCs)
what happens to DCs once they are activated
- increase expression of receptors and adhesion molecules that target DCs to lymphatics and lymphoid tissues
- increases processing of antigen
- induced expression of co stimulatory molecules (immature DCs dont express these)
- increase expression of MHC molecules (increase number of MHC:peptide combinations)
- results in an activated DC capable of priming naive T cells
- priming=first contact that the T cell has with their Ag
what are the changes that DCs go through
what are the different types of DCs and their characteristics
pDC do not migrate to secondary lymphoid organs
innate only
the potent antigen presenting ones are the cDC
diagram of activated DC travel
how do DCs enter the lymph node
enter via afferent lymphatic
how do T and B cells enter the lymph node
enter through high endothelial venules (HEV) (blood circulation
HEV: post capillary venules found in lymph nodes
how are antigens transferred from DC to DC
how do lymphocytes travel
where do T cells enter and leave the lymph nodes
what happens when the T cell finds its match in the lymph node
when they become effector T cells that is when they leave
