31 - B CELLS 5 Flashcards
structure of a TCR
what are the segments of each chain of the TCR
where does the combinatorial diversity of TCR come from
what are the similarities and differences in V(D)J recombination of TCR with BCR
characteristics of TCR CDRs
what is allelic exclusion
how does allelic exclusion work
which are the antibodies secreted by mature naive B cells
alternative splicing
B cells produce long primary mRNA transcript that is differentially spliced to yield either of two distinct mRNA molecules
secreted and transmembrane mRNA are the result of RNA splicing too
what are the isotypes of heavy chains
what are the classes of Igs
how do B cells switch from producing the standard IgM and IgD to the other subtypes?
in the secondary lymphoid follicle aka the germinal centre
B cells undergo processes to produce antibodies that are more effective by:
somatic hypermutation
affinity maturation
class switching
what is secondary diversification
what is somatic hypermutation
what is class switching
take home message: cytokines secreted by TFh in the germinal center will inform class switching
summary
