2- OVERVIEW PART 1 Flashcards
what are the four major categories of pathogens?
viruses
parasites
bacteria
fungi
immune response is quickly tailored to the type of microorganism involved
what is the key major difference between pathogens that changes the immune response?
intracellular (virus) or extracellular (bacteria)
processed differently and generate different types of responses
what are the two interconnected systems in response to pathogens?
innate: first line, fast but not specific
adaptive: highly diverse and specific
immune response=innate+adaptive
what are the key components in the body important for the immune system? (organs and tissues)
bone marrow
thymus
lymphatics (lymphatic system)
lymph nodes
immune cells travel in the body and occupy different tissues over time
what are the primary/central lymphoid organs?
where immune cells are generated
bone marrow and thymus
what are the peripheral/secondary lymphoid organs?
the origin of immune cells
we don’t know if HSC is pluripotent or multipotent
what are the two main lineages of immune cells?
myeloid: innate immunity
lymphoid: adaptive
what lineage do dendritic cells come from?
they connect innate to adaptive immunity
from which lineage are granulocytes and what do they do
from the myeloid lineage
what do megakaryocytes do
give rise to platelets (blood clotting)
monocytes characteristics
antigens is what triggers our immune response
which cells are specialised for phagocytosis
that is how dendritic cells bridge the gap
what are the three main types of cells that develop from the common lymphoid progenitor?
NK=natural killer
ILC=innate lymphoid cells
lymphocytes and specificity
what is the function of molecules in the immune system
what are the key types of molecules in the immune system?
secreted proteins in the immune system and receptor
what is an antigen
immune response summary
