4 - INNATE 1 Flashcards
what are anatomical barriers to infection
pathogens enter through mucosal and epithelial surfaces
pathogens must enter the body, breach those barriers and there are different routes of ntry
what are the tissues and physical elements of innate immunity
what are the cellular elements to innate immunity
what are some key molecules of innate immunity
antimicrobial enzymes (lysozyme -> digest peptidoglycan)
antimicrobial peptides (defensins ->disrupt cell membrane
complement proteins
what is phagocytosis
what is phagocytosis mediated by
what can phagocytosis lead to
DAMPs=damage associated molecular patterns
what are the receptors involved in phagocytosis
what are the steps of phagocytosis
what types of cytoplasmic granules do neutrophils contain and what do they do
what are the processes that kill the phagocytosed pathogens
how does oxidative attack on phagocytosed pathogen work
how is the phagolysosome involved in innate and adaptive immunity
how is phagocytosis a major mode of clearance of cells
some tumour cells have elevated levels of CD47-> tumour progression
how do neutrophils work and do phagocytosis
what are microglia
what is multiple sclerosis
