17 - T CELLS 1

Question 1

what are some examples of some roles of different effector T cells

Answer 1

Question 2

where do T cells go after they exit the lymph node

Answer 2

exit via the efferent lymphatic vessels -> thoracic duct -> blood stream
go to the site of infection

Question 3

what is signal 3 in T cell activation

Answer 3

differentiation
cytokines direct T cell differentiation into the distinct effector cell types

Question 4

what can activated T cells differentiate into after proliferation

Answer 4

Question 5

how are effector T cells classified

Answer 5

effector T cells are the result of activated differentiated T cells
they can be classified based on:
- the TFs they express
- the cytokine profile they make
- their main function in adaptive immunity

Question 6

what do Naive CD8+ T cells differentiate into

Answer 6

Question 7

how do naive vs activated T cells express different cell surface molecules and what is an example of one such comparison

Answer 7

Question 8

take home message (little summary)

Answer 8

Question 9

what are polarizing cytokines and some examples

Answer 9

Question 10

what is the difference between polarizing cytokines and effector cytokines

Answer 10

Question 11

how does signal 3 happen?

Answer 11

Question 12

what are polarizing cytokines secreted by

Answer 12

secreted by the DC, neighboring innate and adaptive immune cells
different STAT proteins are activated within each cell

Question 13

Answer 13

each naive CD4 T cell must express all of the STAT proteins
they must all be there, just waiting to be phosphorylated

Question 14

summary

Answer 14