20 - T CELLS 3 Flashcards
what do CTLs secrete and what does that do
IFN gamma is a cytokine
reminder: difference between type I and type II IFN
type II IFN is secreted mainly by T cells
summary of how CTLs act by
often require CD4+ T cells to help to be activated
what are the different subsets of CD4+ T cells
Th1
Th2
Th17
Tfh
based on what the infection is, the cell mediated response is dominated by one of the T cell subsets
what are Th1 responses involved in
viruses and intracellular pathogens
what are Th2 responses involved in
parasites (helminths) and other extracellular pathogens
and allergies
what are Th17 responses involved in
extracellular bacteria and fungi and autoimmunity
what are Tfh responses involved in
Tfh responses involve activating B cells in the lymph node
key effector molecules and cytokines to remember for CD8 cells and CD4 cells
cross regulation in CD4 cells and what does that make sure of
makes sure that there is one subtype that predominates the response
how does Th1/Th2 cross regulation happen
how is the decision made between Th17/Treg
which cells migrate to infection vs which cells stay in lymph node
leave lymph node and migrate to site of infection: Th1, Th2, Th17
stay at lymph node: Tfh
take home message of cell surface molecules of naive vs effector T cells
different cell surface molecules are expressed by naive vs effector T cels since they travel to different locations in the body
summary
what is signal 3 (polarizing cytokines) for Th1
IFN gamma and IL-12
what is the effector cytokine of Th1
IFN gamma
what is the master transcriptional regulator of Th1
T-bet
what does Th1 activate and what is its response
CD40: activates DCs for cross presentation
signals involved in differentiation into Th1
what are the functions of Th1
