24 - T CELLS 6 Flashcards
what does negative regulation involve
involved receptors, mechanisms and cell types
what happens to the immune response after 10-14 days?
after the Ag is removed, most lymphocytes are no longer required and undergo apoptosis
Tred cells may also help to quell responses by releasing inhibitory cytokines
most newly generated B and T cells are lost at the end of the primary immune response
what is the intrinsic pathway to cell death
what is the extrinsic pathway to cell death
which cells are left behind after majority of T cells die?
what does CTLA-4 do?
what allows CTLA-4 to be expressed on the membrane?
how does CTLA-4 bind B7 molecules
when CTLA-4 expression induced?
what is PD-1 and what does it do
what is signal 3, effector cytokines and master transcriptional regulatory of iTreg cells?
what are the two Treg subsets
natural and induced (adaptive)
characteristics of natural Tregs
characteristics of induced (adaptive) Tregs
what is the signaling of iTregs
what are the ways in which Treg cells negatively regulate the immune response
how do IL-10 and TGF-beta work?
what peptides are Tregs specific to?
what to Tregs do once they recognise its p:MHC on an APC
summary
