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Immunology And Serology BOARD EXAM > 8th Page > Flashcards

8th Page Flashcards

1
Q

What are the ways of killing by cytotoxic T cells?

A
  1. Apoptosis (through intracellular signaling)
  2. Release the contents of granules that damage the cell
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2
Q

Granzyme B

A

Activate a nuclease that destroys the target cell DNA.

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3
Q

Perforin

A

Pore-forming proteins that polymerize in the presence of Calcium and form channels in the target cell membrane.

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4
Q

CD2

A

Involved in T cell activation (Rosette formation).

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5
Q

CD3

A

Found on all T cells; associated with T-cell antigen receptor.

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6
Q

CD4

A

Identifies T helper cells; also found on most T regulatory cells.

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7
Q

CD4?

A

Co-receptor for MHC Class I.

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8
Q

CD10?

A

Protease; marker for pre-B CALLA

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9
Q

CD19?

A

Part of B-cell coreceptor; regulates B-cell development and activation.

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10
Q

CD21?

A

Receptor for complement component C3d; part of B-cell coreceptor with CD19.

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11
Q

CD23?

A

Regulation of IgE synthesis; triggers release of GM-CSF from monocytes.

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12
Q

CD25?

A

Receptor for IL-2.

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13
Q

CD44?

A

Adhesion molecule mediating homing to peripheral lymphoid organs.

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14
Q

CD45R?

A

Essential in T and B cell antigen-stimulated activation.

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15
Q

CD50?

A

Function: Cell adhesion and signaling.

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16
Q

CD94

A

Function: Subunit of NKG2-A complex involved in inhibition of NK cell cytotoxicity.

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17
Q

Function: Positive or negative modulation of T and B cell receptor signaling

A

CD5

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18
Q

Function: Identifies cytotoxic T cells

A

CD8

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19
Q

Function: Co-receptor for MHC Class I

A

CD8

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20
Q

Thymocytes, T cells, NK cells

A

CD2

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21
Q

Thymocytes, T cells

A

CD3

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22
Q

T helper cells, monocytes, macrophages

A

CD4

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23
Q

Mature T cells, thymocytes, subset of B cells

A

CD5

24
Q

B and T cell precursors, bone marrow stromal cells

A

CD10

25
Q

Thymocyte subsets, cytotoxic T cells

A

CD8

26
Q

B cells, follicular dendritic cells

A

CD19, CD21

27
Q

Macrophages NK cells, neutrophils

A

CD16

28
Q

B cells, follicular dendritic cells, monocytes

A

CD23

29
Q

Activated T, B cells, monocytes

A

CD25

30
Q

Most leukocytes

A

CD44

31
Q

Different forms on all hematopoietic cells

A

CD45R

32
Q

NK cells, subsets of T cells

A

CD56, CD94

33
Q

Double negative T cells

A

lack CD4 and CD8 markers

34
Q

Double negative T cells

A

actively proliferate in the outer cortex under the influence of IL-7

35
Q

Double negative T cells

A

undergo rearrangement of the genes that code for the antigen receptor known as TCR

36
Q

Double positive T cell

A

Express both CD4 and CD8

37
Q

Positive selection in Double Positive T cell maturation

A

occurs in the thymic cortex

38
Q

T cells must recognize foreign antigen in association with class I or class II MHC molecules, allowing only double-positive cells with functional TCR receptors to survive.

A

Positive selection in Double Positive T cell maturation

39
Q

Helper or inducer cells

A

CD4+

40
Q

Negative selection in Double Positive T cell maturation

A

occurs in the thymic medulla

41
Q

eliminating T cells that react strongly with self-peptides presented by MHC molecules through apoptosis.

A

Negative selection in Double Positive T cell maturation

42
Q

Medulla

A

Survivors of selection exhibit only one type of marker, either CD4 or CD8, and they migrate to?

43
Q

CD4+ T cells

A

recognize antigens in MHC Class II

44
Q

produces IFN-γ, IL-2, TNF-Beta

A

Th1

45
Q

Responsible for activation of cytotoxic T lymphocytes and macrophages

A

Th1

46
Q

helps B cells produce antibodies against extracellular pathogens.

A

Th2

47
Q

Produces IL-4, IL-5, IL-10, and IL-13

A

Th2

48
Q

Has a role in suppressing the immune response to self-antigens and preventing autoimmunity.

A

T reg

49
Q

Possess the CD4 antigen and CD25

A

T reg

50
Q

T cells exposed to antigen

A

Activated T cells

51
Q

Expressed receptors for IL2, just as activated B cells

A

Activated T cells

52
Q

What is the receptor for IL-2 in Activated T cell?

A

CD25+

53
Q

What is the normal ratio of CD4+:CD8+ cells?

A

2:1

54
Q

What is the CD4+:CD8+ cell ratio in HIV?

A

1:2
or
0.5:1

55
Q

What is the CD4+ cell count in AIDS?

A

less than 200 cells/mm³.

Immunology And Serology BOARD EXAM (32 decks)

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