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Immunology And Serology BOARD EXAM > 12th Page > Flashcards

12th Page Flashcards

(67 cards)

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1
Q

What is the approximate molecular weight of a light chain?

A

~25 kDa

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2
Q

How many amino acids are in a light chain?

A

~220 amino acids

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3
Q

What are the two types of light chains?

A

Kappa (k) and Lambda (λ) chains

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4
Q

Which chromosome is the Kappa light chain located on?

A

Chromosome 2

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5
Q

Which chromosome is the Lambda light chain located on?

A

Chromosome 22

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6
Q

Are both Kappa and Lambda light chains found in all 5 classes of immunoglobulin?

A

Yes, but only one type is present in a given molecule.

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7
Q

What is the approximate molecular weight of a heavy chain?

A

~50 - 70 kDa

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8
Q

How many amino acids are in a heavy chain?

A

~440 amino acids

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9
Q

Which chromosome is the heavy chain located on?

A

Chromosome 14

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10
Q

Ig type in Heavy Chain (GAMED)

A

They are unique to each class and give each Ig type its name: IgG, IgA, IgM, IgE, IgD.

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11
Q

What is the difference between allotype and idiotype?

A

Allotype refers to variations in constant regions (Gm groups), while idiotype refers to variations in variable regions.

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12
Q

Same heavy chain for each class/ H chain that is unique to each antibody

A

Isotype

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13
Q

Hinge region in Heavy chain is located where?

A

It is located between CH1 and CH2.

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14
Q

What is a characteristic finding in the urine of a patient with multiple myeloma?

A

BJP - Bence Jones Proteins

Light chains are found in the urine.

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15
Q

What are the two distinct regions contained in each light and heavy chain?

A

Variable (V) regions and Constant (C) regions.

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16
Q

How many amino acids of the N-terminal in a light chain are in variable region

A

First 110 amino acids

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17
Q

Variable region is also called?

A

Complimentary Determining region

Hypervariable regions

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18
Q

How many constant regions are in a light chain?

A

Single constant region.

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19
Q

How many constant regions are typically found in heavy chains?

A

3 - 4 constant regions.

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20
Q

What forms the basis of antibody classification?

A

Constant regions.

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21
Q

Domains

A

regions in Ab molecule

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22
Q

Components of IgG, IgA, IgD

L-1:1
H-1:3

A

The light chain has 2 domains: 1 VL and 1 CL.

The heavy chain has 4 domains: 1 VH and 3 CH.

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23
Q

What are the components of IgM and IgE?

L-1:1
H-1:4

A

1 light chain (2 domains: 1 VL and 1 CL)

1 heavy chain (5 domains: 1 VH and 4 CH).

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24
Q

Proteolytic/Chemical treatment of immunoglobulins.

A

Pepsin
Papain
Mercaptoethanol

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25
What Ig has monomer structure?
Ig GADE
26
What is the structure of IgA?
Monomer and Dimer
27
What is the structure of IgM?
Pentamer
28
What Ig has 75 sedimentation coefficient?
Ig GAD
29
What Ig has 195 sedimentation coefficient?
IgM
30
What Ig has 85 sedimentation coefficient?
IgE
31
What is the molecular weight of IgG?
150,000
32
What is the molecular weight of IgA?
160,000
33
What is the molecular weight of IgM?
900,000
34
What is the molecular weight of IgE?
190,000
35
What is the molecular weight of IgD?
180,000
36
What is the percent of total immunoglobulin? IgG
70-75
37
What is the percent of total immunoglobulin? IgA
10-15
38
What is the percent of total immunoglobulin? IgM
10
39
What is the percent of total immunoglobulin? IgD
<1
40
What is the percent of total immunoglobulin? IgE
0.002
41
What is the serum half-life of IgG?
23 days
42
What is the serum half-life of IgA?
5 days
43
What is the serum half-life of IgM?
6 days
44
What is the serum half-life of IgD?
1-3 days
45
What is the serum half-life of IgE?
2-3 days
46
What Ig has C' fixation?
Ig GM
47
What Ig has no C' fixation?
Ig ADE
48
Does Ig only cross the placenta?
IgG
49
What are the subclasses of IgG?
IgG1, IgG2, IgG3, and IgG4. ## Footnote They are numbered according to their abundance in the serum: IgG1 > IgG2 > IgG3 > IgG4.
50
Which IgG is the most abundant in blood?
IgG ## Footnote It constitutes approximately 67% of IgG subclasses.
51
Which IgG subclass is most efficient in crossing the placenta?
IgG1 ## Footnote IgG2 cannot cross the placenta.
52
Which IgG subclass is most efficient in complement fixation?
IgG3 ## Footnote It has the longest hinge region.
53
Which IgG subclass cannot fix complement?
IgG4
54
Which IgG subclass cannot cross the placenta?
IgG 2
55
IgG3
longest hinge region among IgG subclasses
56
Ig of longest half-life
IgG
57
Ig with long term immunity
IgG
58
Warm antibodies
IgG
59
Predominant antibody in secondary
IgG
60
Ig of anamnestic immune response
IgG
61
Chronic Ig
IgG
62
Non-agglutination Ig
IgG
63
How many disulfides are there in IgG 1 (67%)
2 disulfide bonds.
64
How many disulfides are there in IgG2 (22%)
4 disulfide bonds
65
How many disulfides are there in IgG3 (7%)
15 disulfide bonds
66
How many disulfides are there in IgG4 (4%)
2 disulfide bonds
67
What role do macrophages, monocytes, and neutrophils play regarding IgG?
They have receptors on their surfaces that are specific for the FC region of IgG, enhancing contact between antigen and phagocytic cells, and increasing the efficiency of phagocytosis.

Immunology And Serology BOARD EXAM (32 decks)

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