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Immunology And Serology BOARD EXAM > 29th Page > Flashcards

29th Page Flashcards

1
Q

What are the markers for Hepatitis B?

A

HBsAg, Anti-HBc, Anti-HBs

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2
Q

No exposure/ Candidate for immunization

A

All negative in HBsAg, Anti-HBc, Anti-HBs

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3
Q

Infected early stage

A

HBsAg- pos
Anti-HBc- neg
Anti-HBs-neg

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4
Q

Acute/Chronic

A

HBsAg- pos
Anti-HBc- pos
Anti-HBs- neg

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5
Q

Window phase

A

HBsAg- neg
Anti-HBc- pos
Anti-HBs- neg

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6
Q

Immune bec. of vaccination

A

HBsAg- neg
Anti-HBc- neg
Anti-HBs- pos

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6
Q

Immune bec. of infection

A

HBsAg- neg
Anti-HBc-pos
Anti-HBs- pos

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7
Q

What is the average incubation period for Hepatitis C (HCV)?

A

15-150 days

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8
Q

What percentage of chronic hepatitis occurs in Hepatitis C?

A

40-60%

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9
Q

What is the mortality rate for Hepatitis C?

A

0.5-1.0%

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10
Q

What tests are used to detect current Hepatitis C infection?

A

HCV RNA for confirmation

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11
Q

What does a nonreactive NAT suggest?

A

A past HCV infection or false-positive antibody test result.

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12
Q

monitor effectiveness of therapy and determine HCV genotype

A

HCV RNA Viral Load

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13
Q

family of HCV

A

Flaviviridae

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14
Q

Non-A Non-B Hepatitis

Post-transfusion hepatitis

A

HCV

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15
Q

MOT of HCV

A

Sexual
Parenteral
Perinatal/vertical
Blood transfusion

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16
Q

Hepatitis D (HDV) requires what?

A

HBV for its replication.

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17
Q

What are the markers for Hepatitis D?

A

Anti-HDV IgM
Anti-HDV IgG
HDV RNA
C-infection
super infection
chronic infection

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18
Q

What is the mode of transmission for Hepatitis E (HEV)?

A

Fecal-oral; mostly through contaminated drinking water.

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19
Q

What is the mortality rate of Hepatitis E in pregnant women?

A

20% to 25% due to obstetric complications.

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20
Q

What are the markers for Hepatitis E?

A

IgM Anti-HEV
IgG Anti-HEV
HEV RNA

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21
Q

What is the mode of transmission for Hepatitis G (HGV)?

BT

A

Blood-borne route
Tansplacental (rarely).

22
Q

Molecular Assays quantitative

A

performed RT-PCR, real-time PCR, or bDNA ampflication

monitor amount of HCV RNA viral load

23
Q

Molecular Assays qualitative

A

Detect presence or absence of HCV RNA
Confirm infection HCV Ab-pos
Detect infection in Ab-neg
Screen blood and organ donors
Detect perinatal infections in babies born to HCV-pos

24
Q

Delta hepatitis, ssRNA (Delta Ag), spherical in shape

A

HDV

25
Q

A defective virus

requires obligatory helper functions from HBV to ensure replication and infectivity.

A

HDV

26
Q

HBV provides HDV with a protein coat of ?

A

HBsAg

26
Q

Primarily transmitted by _______ means and is commonly severe

A

parenteral

27
Q

SIMULTANEOUS infection of HDV with HBV,

A

Coinfection

28
Q

additional HDV infection in patients with chronic HBV infection

A

Superinfection

29
Q

without chronic infection

A

Coinfection

30
Q

with chronic infection

A

Superinfection

31
Q

Elevated in acute phase

A

Anti-HDV IgM

31
Q

Produced in the convalescence phase

A

Anti-HDV IgG

32
Q

Active HDV infection

A

HDV RNA

32
Q

May be used to monitor effectiveness of therapy

A

HDV RNA

33
Q

Used to confirm a positive HDV antibody screen

A

HDV RNA

34
Q

Presence of IgM anti-HDV + HBsAg + IgM anti-HBc

A

Co-infection

35
Q

Absence of IgM anti-HBc + Positive anti-HDC + IgG Anti-HBc

A

Superinfection

36
Q

Presence of anti-HD

A

Chronic infection

37
Q

Family of HEPATITIS E (HEV)

A

Calciviridae (ssRNA)

38
Q

Calciviridae (ssRNA) in HEV reclassified to

A

Hepeviridae

39
Q

Presents as an acute, self-limiting hepatitis without progression to chronic state

A

HEV

40
Q

Current/new hepatitis E infection

NM

A

IgM Anti-HEV

41
Q

Current/former hepatitis E infection

FG

A

IgG Anti-HEV

42
Q

detect px in the later stages of infection; determine past exposure

A

IgG Anti-HEV

43
Q

identify seroprevalence of the infection in a population

A

IgG Anti-HEV

43
Q

Current hepatitis E infection

A

HEV RNA

44
Q

nucleic acid can be performed by realtime PCR or a loop-mediated isothermal amplification assay (LAMP)

A

HEV RNA

44
Q

can be detected just before clinical symptoms.

A

HEV RNA

45
Q

becomes undetectable in the blood about 3 weeks after symptom onset; in the stool, it becomes undetectable at about 5 weeks.

A

HEV RNA

46
Q

A negative result for does not exclude the possibility of a recent infection

A

HEV RNA

47
Q

2 independent viruses in HGV

A

HGV and GBV-C

48
Q

Family of HGV

A

Flaviviridae (ssRNA)

Immunology And Serology BOARD EXAM (32 decks)

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