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Immunology And Serology BOARD EXAM > 13th Page > Flashcards

13th Page Flashcards

1
Q

IgA

A

provides natural passive immunity

predominant in body secretions such as tears, saliva, colostrum, milk, and intestinal fluids.

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2
Q

What are the subclasses of IgA?

A

IgA1, which is a monomer found in serum

IgA2, which is a dimer found in secretions, held together by a J chain.

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3
Q

How does IgA protect itself during transport?

A

IgA binds to a glycoprotein (secretory component)

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4
Q

Protects IgA from digestion by proteolytic enzymes and facilitates its transport to mucosal surfaces

A

Secretory component

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5
Q

IgM

A

largest antibody (megastar)

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6
Q

primary response antibody.

A

IgM

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7
Q

What are the forms of IgM?

A

monomer or a pentamer

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8
Q

IgM has how many antigen binding sites that are available for effector functions due to steric hindrances

A

5-6

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9
Q

IgM reacts at what temperature?

A

COLD

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10
Q

first antibody formed by the fetus

A

IgM

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11
Q

IgM

A

IgM is the first antibody to appear during an immune response and is the last to leave in senescence.

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12
Q

IgM

A

most efficient antibody that activates the complement system.

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13
Q

Agglutinating Ig

A

IgM

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14
Q

Cold-reacting Ab

A

IgM

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15
Q

Acute Infection Ig

A

IgM

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16
Q

Has the longest hinge region

A

IgD

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17
Q

IgD

A

found on the surface of mature and naive B cells in association with IgM.

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18
Q

What role does IgD play in B cells?

A

antigen recognition by B cells and signals B cells for antibody production.

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19
Q

Extremely susceptible to proteolysis

A

IgD

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20
Q

Drive B cells to produce antibody for immunoregulation

A

IgD

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21
Q

Antibody for hypersensitivity

A

IgE

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22
Q

Antibody that defense against parasitic worm?

A

IgE

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23
Q

IgE

A

least abundant immunoglobulin in the serum.

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24
Q

IgE

A

most heat labile antibody

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25
Q

Reaginic antibody

A

IgE

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26
Q

IgE

A

binds strongly to receptors on mast cells and basophils, mediating the release of histamine and heparin.

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27
Q

IgE

A

IgE mediates some types of hypersensitivity reactions, allergies, and anaphylaxis.

28
Q

Generally responsible for immunity to invading pararsites (IL-4)

A

IgE

29
Q

greatest plasma concentration

A

IgG

30
Q

body secretions (saliva, tears)

A

IgA

31
Q

mega (largest)

A

IgM

32
Q

activates complement easily

A

IgM

33
Q

pentaMer

A

IgM

34
Q

Drive B cells

A

IgD

35
Q

Allergy

A

IgE

36
Q

Lag phase

A

No antibody is detectable.

This phase is known as the ‘1a9 phase’.

37
Q

Log phase

A

The antibody titer increases logarithmically.

This indicates a rapid increase in antibody levels.

38
Q

Plateau phase

A

The antibody titer stabilizes.

This phase is characterized by a steady level of antibodies.

39
Q

Decline phase

A

The antibody is catabolized.

This phase marks the decrease in antibody levels.

40
Q

What defines the primary antibody response?

A

It is the first immune response to the first encounter with a specific immunogen.

This includes a longer lag phase and lower antibody titer.

41
Q

Initial challenge of the immune system

A

Primary antibody

42
Q

Characteristics of the primary antibody response?

A
  1. Predominant antibody produced: IgM
  2. Longer lag phase
  3. Decrease/low antibody titer
43
Q

Secondary (anamnestic) antibody response?

A

It is the immune response to subsequent exposure to the same antigenic stimulus.

This response is faster and stronger.

44
Q

Characteristics of the secondary antibody response?

A
  1. Predominant antibody produced: IgG
  2. Shorter lag phase
  3. Longer stationary/plateau phase
  4. More gradual decline phase
  5. Increase in antibody titer
  6. Faster and stronger response
45
Q

Most abundant Ab in the body

A

IgA

46
Q

Most abundant Ab in serum

A

IgG

47
Q

Ratio of IgG to IgA in serum

A

10:1

48
Q

Least abundant Ab in the serum

A

IgE

49
Q

Most effective in complement fixation

A

IgM

50
Q

Longest hinge region

A

IgD

51
Q

Longest hinge region in IgG classes

A

IgG3

52
Q

Incomplete or non-agglutinating Ab

A

IgG

53
Q

Significant Ab type often implicated in HTR and HDN

A

IgG

54
Q

IgG that cannot cross the placenta

A

IgG2

55
Q

IgG that is most efficient in complement fixation

A

IgG3

56
Q

IgG that CANNOT fix complement

A

IgG4

57
Q

IgGs that have high affinity to Fc receptors of phagocytic cells, increasing efficiency of phagocytosis

A

IgG1 and IgG3

58
Q

An excellent neutralizing Ab

A

IgG

59
Q

The only Ab with secretory components

A

IgA

60
Q

Major Ab found in the colostrum in the mother’s milk

A

IgA

61
Q

Ab most often formed in response to Gram (-) bacteria

A

IgM

62
Q

Last to leave in senescence

A

IgM

63
Q

First Ab that is formed by the fetus

A

IgM

64
Q

First Ab to appear during an immune response

A

IgM

65
Q

Abs in the membrane of B cells

A

IgM, IgD

66
Q

Most heat-labile Ab

A

IgE

Immunology And Serology BOARD EXAM (32 decks)

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