3rd Page Flashcards
What is the mechanism of Cellular Immunity?
Cell-mediated
Defense against Viral / Fungal infections (Intracellular) and Delayed Hypersensitivity.
What is the cell type in Cellular Immunity?
T cell/ Lymphokines
What is the mode of action of Cellular Immunity?
Direct cell-to-cell contact or secreted products (e.g. cytokine)
What are the purpose in Cellular Immunity?
Defense against Viral/Fungal infections (intracellular)
What are the remarks in Cellular Immunity?
Delayed Hypersensitivity
What are the steps in Cellular Immunity?
- Exposure to pathogen
- Pathogen enters a body cell.
- Ags of the pathogen are displayed on the infected cells.
- Phagocyte swallows and destroys the pathogen.
- Phagocyte displays the Ags of the pathogen.
- Inactivated T cell binds to the APCs.
- Proteins activate the T-cell and it divides into:
• Memory T cell
• Active Plasma T cell
Proteins activate the T-cell in cellular immunity and it divides into 2:
- Memory T cell
- Active Plasma T cell
What is the mechanism of Humoral Immunity?
Humoral-mediated
Defense against bacterial infections (Extracellular) and Antibody Dependent Cellular Cytotoxicity (ADCC).
What is the mode of action of Humoral Immunity?
Antibodies circulating in serum
What is the cell type in Humoral Immunity?
B cells / Plasma cells
What are the steps in Humoral Immunity?
- Exposure to pathogen
- Membrane-bound Abs of B Cell will bind to the pathogen.
- Pathogen engulfed by the B-cell and broken down.
- Ags on the pathogen displayed on the B-cell.
- Helper T cell binds to the Antigen-presenting B-cell.
- Proteins activate the B-cell.
- B-cell divides into:
• Memory B cell
• Active B cell
Acute Phase Reactant: CRP
Response Time
6-10 hrs
Acute Phase Reactant: Serum Amyloid A
Response Time
24 hrs
Acute Phase Reactant: Alpha 1 anti-trypsin
Response Time
24 hrs
Acute Phase Reactant: fibrinogen
Response Time
24 hrs
Acute Phase Reactant: haptoglobin
Response Time
24 hrs
Acute Phase Reactant: ceruloplasmin
Response Time
48-72 hrs
Acute Phase Reactant: C3
Response Time
48-72 hrs
Acute Phase Reactant: CRP
Normal values
0.5 mg/dL
Acute Phase Reactant: Serum Amyloid A
Normal values
3.0 mg/dL
Acute Phase Reactant: Alpha 1- anti-trypsin
Normal values
200-400 mg/dL
Acute Phase Reactant: fibrinogen
Normal values
110-400 mg/dL
Acute Phase Reactant: haptoglobin
Normal values
40-200 mg/dL
Acute Phase Reactant: ceruloplasmin
Normal values
20-40 mg/dL
Acute Phase Reactant: C3
Normal values
60-140 mg/dL
Acute Phase Reactant: CRP
Increase
1000x