42. Genus Mycobacterium (antigens, resistance). Obligate pathogenic Mycobacterium species.

Question 1

Biochemistry and Antigens?

Answer 1

5. Biochemistry:
   • not examined in diagnostic work
6. Antigens:
   • glycolipids, lipoproteins,
   • close relationship of antigens,
   • cross reactions
   • immuno-electrophoresis
   • tuberculin
   • antigen extract: diagnostic
   • old tuberculin
   • broth culture, boiled, filtered, concentrated
   • PPD (purified protein derivate)
   • trichloroacetic acid precipitation

Question 2

Resistance and Pathogenecity?

Answer 2

7. Resistance:
   • excellent
8. Pathogenicity:
   • obligate pathogens
   • tuberculosis, paratuberculosis
   • facultative pathogens (atypical)
   • mycobacter

Question 3

Species?

Answer 3

9. Species
   • identification of species
   • morphology
   • culture
   • (biochemistry)
   • genome structure
   • 16S rRNA
   • pathogenicity
   • pathogenic mycobacteria: genogroups (complexes)
   • M. tuberculosis-complex
   • M. avium-complex
   • M. leprae, M. lepraemurium

Question 4

Obligate Pathogenic Mycobacterium species?

Answer 4