4.12 HTN and Dyslipidemia Flashcards
Skipped HTN because not on exam apparently
Atherosclerosis begins in ___ Its presence and severity is linked to the presence and severity of ___ including dyslipidemia.
youth
CV risk factors
What genetic condition is common in children and results in dyslipidemia
familial hypercholesterolemia
Identification and treatment of FH in childhood significantly reduces, and possibly normalizes, CV risk in adulthood.
What should be done within the first 10 years of life (after age 2) to detect familial hypercholesterolemia
universal lipid screening
screening = fasting or non fast HDL or LDL
(“Expert Panel guidelines”) that recommended universal nonfasting lipid screening of all children between 9 and 11 years of age and again at 17-21 years of age, with the aim of improving the detection of inherited lipid disorders such as FH
Which peds should undergo selective lipid screening for dyslipidemia
those >2 with positive fam hx of premature CVD
or medical conditions like T2DM
What is the first line treatment for ped dyslipidemia
lifestyle and diet changes
At what age can statins be initiated if lifestyle changes are not effective
Patients with persistent hypertriglyceridemia (2.3-5.5 mmol/L) despite lifestyle interventions or severe (> 5.5 mmol/L) hypertriglyceridemia at diagnosis may be considered for pharmacotherapy in addition to strict dietary management, including the use of prescription omega-3 fatty acids or fibrates, although evidence of benefit and safety are limited for children, and evaluation and management by a lipid specialist is recommended.
age 8-12 years old
evaluation and management by a lipid specialist is recommended
What is secondary dyslipidemia
dyslipidemia caused by lifestyle factors as opposed to family genetics
typically presents with mild-to-moderate hypertriglyceridemia and low HDL-C, but the underlying CV risk relates to increased numbers of small, dense LDL particles.
