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FD9 > 41 - Urticaria and Angioedema > Flashcards

41 - Urticaria and Angioedema Flashcards

1
Q

Local transient skin or mucosal edema and an area of redness that diminish within a day

A

Urticaria

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2
Q

Local and transient skin is mucosal edema that develops in deep tissue mostly without itching but may accompany pain or burning sensations

A

Angioedema

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3
Q

Nonacute or chronic urticaria

A

Persist for more than 6 weeks

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4
Q

Chronic spontaneous urticaria CS can be divided into

A

With concomitant angioedema
Without angioedema
Recurrent angioedema without wheals

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5
Q

Women have urticaria nearly _____ as often as men do

A

Twice

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6
Q

Edema that involves the superficial portion of the dermis

A

Wheals

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7
Q

Edema that extends into the deep dermis or subcutaneous and submucosal layers

A

Angioedema

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8
Q

Y/N: Angioedema may be painful and pruritic

A

No - painful but not pruritic

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9
Q

The heterogeneity of wheals in size and shape is one of the characteristics of

A

Spontaneous urticaria

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10
Q

The duration of individual wheals is long in _____ and shorter in _____

A

Spontaneous urticaria and deep pressure urticaria

Physical urticaria

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11
Q

Angioedema is rare in

A

Physical urticaria

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12
Q

Flowerlike or annular-shaped wheals are characteristic of

A

Spontaneous urticaria

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13
Q

(Acute/Chronic) spontaneous urticaria tends to be more severe

A

Acute

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14
Q

Most common subtype among the physical urticarias

A

Mechanical urticaria or dermographism

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15
Q

Rare and severe case of symptomatic dermographism with erythematous lines accompanied by punctate wheals characteristic of cholinergic urticaria

A

Cholinergic dermographism

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16
Q

Wheals of symptomatic dermographism may return in the same site or newly develop 3-6 hours after stimulation and persist for up to 48 hours

A

Delayed dermographism

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17
Q

Wheals of symptomatic dermographism may be markedly augmented when the skin is chilled

A

Cold-dependent dermographism

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18
Q

Local skin contact with a cold substance induces wheals and flare

A

Cold contact urticaria

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19
Q

Erythematous edematous and deep swelling may appear 9-18 hours after cold challenge

A

Delayed cold urticaria

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20
Q

Widespread wheals and flare develop in response to cooling of the core body temperature

A

Systemic cold urticaria

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21
Q

Familial cold urticaria syndrome is classified as a subtype of

A

Cryopyrin-associated periodic syndrome

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22
Q

Cryopyrin-associated periodic syndrome is an autosomal dominant inherited disease which is associated with a genetic mutation of

A

NLRP3 (CIASI)

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23
Q

Develop wheals and flare that spread in the area of skin exposed to heat, regardless of the core body temperature or sweating

A

Heat urticaria

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24
Q

Y/N: In solar urticaria, face and hands may develop fewer lesions than skin areas that are usually covered by clothes

A

Yes - because of hardening due to chronic exposure to sunlight

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25
Deep dermal wheals that appear in a continuously compressed region
Delayed pressure urticaria
26
Missense mutation of _____ has been reported to be associated with familial vibratory urticaria with autosomal dominant inheritance
ADGRE2
27
Characterized by small wheals, resembling eruption of cholinergic urticaria, but wheals in this urticaria subtype are generally fewer in number compared with eruptions of cholinergic urticaria
Aquagenic urticaria
28
Induced by stimuli that cause sweating and distinctive for its small urticarial eruptions
Cholinergic urticaria
29
Pruritus without wheals induced by conditions that elicit sweating
Cholinergic pruritus
30
Major antigen in sweat has been identified as _____, a protein produced and released be by _____
MGL_1304 | Malassezia globosa
31
Oral edema and discomfort induced by contact of the oral mucosa with certain foods
Oral allergy syndrome
32
Those with hereditary angioedema do not develop
Superficial wheals
33
Most frequent sign of anaphylaxis
Wheal and flare
34
Classical type I allergy against exogenous antigens, such as food and drugs, is less than _____% of the whole population of patients with urticaria
10
35
Dietary pseudoallergens that may be relevant as a cause or a precipitating or aggravating factor for CSU
Salicylates and biogenous amines Food additives Topical or oral NSAIDs
36
For a diagnosis of food pseudoallergy, _____ may be followed by well-motivated patients
3-week pseudoallergen-free diet
37
The increased sensitivity of patients with CSU to _____ in the diet has been suggested as a cause of nonallergic hypersensitivity
Histamine
38
In patients with CSU, especially those with severe symptoms, the levels of _____ are higher than those in healthy control participants
Plasma coagulation markers, such as Prothrombin fragment 1+2 (PF 1+2) Fibrin degradative products (FDPs) D-dimer
39
Known to be associated with spontaneous urticaria, especially with the onset of acute urticaria in children and transient aggravation of CSU
Acute infections by viruses and bacteria
40
_____, which inhibit cyclooxygenase-1, may induced or aggravate wheals and angioedema
Aspirin and other NSAIDs
41
_____ are the most common signs of immediate reactions to contrast media, but delayed nonimmediate reactions may include a _____
Erythema and wheals with or without angioedema | Maculopapular rash
42
Drugs that induced histamine release from mast cells or basophils, especially when given at high doses
``` Opiate analgesics Polymyxin B Curare D-tubocurarine Vancomycin ```
43
Drug that does not cause release or production of mediators by themselves but inhibit degradation of bradykinin
ACE inhibitors
44
CSU may be associated with
Infections | Autoimmune disorders, such as thyroid diseases and collagen diseases
45
Have a higher risk of developing latex allergy
Health care workers Individuals with atopic dermatitis Patients with spina bifida
46
Flares in disease activity during the evening to early morning is not specific but is a common feature of
Spontaneous urticaria
47
Wheals of indictable urticaria do not usually last for more than 4 hours expect
Delayed pressure urticaria
48
_____-mediated angioedema does not usually occur in the larynx
Mast cell
49
_____-mediated angioedema does not accompany superficial wheals
Bradykinin
50
Routine laboratory testing recommended for acute spontaneous urticaria
None
51
Routine laboratory testing recommended for chronic spontaneous urticaria
CBC | ESR or CRP
52
Hereditary angioedema types
I - lack C1-INH protein II - lack activity of C1-INH because of genetic point mutations III - normal C1-INH
53
Acquired angioedema may develop by
Overconsumption of C1-INH caused by myeloproliferative diseases Presence of autoantibodies against C1-INH
54
Characterized by urticaria-like eruptions and monoclonal IgM or IgG gammopathy accompanied by systemic syndrome such as fever and bone and muscle pain
Schnitzler syndrome
55
Schnitzler syndrome histology resembles
Urticarial vasculitis or neutrophilic urticaria
56
Easy and comprehensive method of evaluation for all kinds of urticaria and angioedema
Urticaria Control Test
57
Infiltration of neutrophils is prominent especially in
Acute urticaria | Physical urticaria
58
Mainstay of treatment for all kinds of mast cell-mediated urticaria
Second-generation nonsedating antihistamines
59
Adverse effects of first-generation antihistamines
Carry-over effects of sedation in the morning | Paradoxical excitation or possibly epilepsy in children
60
Second-line therapy for intractable cases resistant to standard doses of antihistamines
Increased dosing of antihistamines up to fourfold
61
Inhibits circulating IgE and consequently decreases the number of high-affinity Ig E receptor on mast cells and basophils
Omalizumab
62
Although it takes 2 months or longer for omalizumab to decrease the number of cell surface high-affinity Ig E receptor, the clinical effect of omalizumab on CST may become apparent within
1 week
63
In most cases of _____, antihistamines are not effective
Delayed pressure urticaria | Urticarial vasculitis
64
Used for treatment of acute attacks of bradykinin-mediated HAE
Icatibant Ecallantide Purified or recombinant C1-INH
65
Used for prophylaxis of bradykinin-mediated HAE
Purified or recombinant C1-INH Lanadelumab BCX7653
66
Y/N: Antihistamines do not cross the plancenta
No - cross the placenta
67
Among antihistamine, _____ is often chosen for pregnant women based on its long bioavailability and safety record
Chlorphenamine
68
All family members of patients with HAE type I and type II who are older than _____ are recommended to undergo screening
1 year old

FD9 (108 decks)

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