28 - Psoriasis Flashcards
Types of psoriasis based on age of onset
Type I - onset before 40 years and HLA associated
Type II - age after 40 years
Also known as isomorphic response
Koebner phenomenon
Koebner reaction usually occurs
7-14 days after injury
Psoriasis vulgaris is seen approximately in _____% of patients
90
Type of psoriasis: lesions may extend laterally and become circinate because of the confluence of several plaques
Psoriasis gyrata
Type of psoriasis: partial central clearing resulting in ringlike lesions
Annular psoriasis
Type of psoriasis: usually associated with lesional clearing and portends a good prognosis
Annular psoriasis
Type of psoriasis: lesions in the shape of a cone or limpet
Rupioid psoriasis
Type of psoriasis: ringlike, hyperkeratotic concave lesion, resembling an oyster shell
Ostraceous psoriasis
Type of psoriasis: thickly scaling, large plaques, usually on the lower extremities
Elephantine psoriasis
Hypopigmented ring surrounding individual psoriatic lesions usually associated with treatment, most commonly UV radiation or topical steroids
Woronoff ring
Pathogenesis of Woronoff ring
Not well understood but may result from inhibition of prostaglandin synthesis
Guttate psoriasis has the strongest association to
HLA-Cw6
Frequently precedes or is concomitant with the onset or flare of guttate psoraisis
Streptococcal throat infection
Common adult presentation of psoriasis in Korea and other Asian countries
Small plaque psoriasis
Characterized by fever that lasts several days and a sudden generalized eruption of sterile pustules; waves of fever and pustules
Generalized pustular psoriasis (von Zumbusch)
Tends to occur after a viral infection and consists of widespread pustules with generalized plaque psoriasis
Exanthematic pustular psoriasis
Exanthematic pustular psoriasis vs von Zumbusch
Exanthematic pustular psoriasis - no constitutional symptoms and tends not to recur
Characterized by pustules on a ringlike erythema that sometimes resembles erythema annulare centrifugum
Annular pustular psoriasis
Variant of pustular psoriasis occuring in pregnancy
Impetigo herpetiformis
Impetigo herpetiformis onset
Early in the third trimester and persists until delivery
Y/N: Impetigo herpetiformis tends to develop earlier in subsequent pregnancies.
Yes
Impetigo herpetiformis is often associated with
Hypocalcemia
Rare variant of pustular psoriasis that is localized to the palms and soles
Palmoplantar pustular psoriasis or
Pustulosis palmaris et plantaris
Palmoplantar pustular psoriasis vs palmoplantar pustulosis
Palmoplantar pustular psoriasis - chronic plaque psoriasis is present
Y/N: Pustulosis palmaris et plantaris has a sex predilection
Yes - more common in females
Strongly associated with pustulosis palmaris et plantaris
Smoking
Also knows as dermatitis repens
Acrodermatitis continua of Hallopeau
Napkin psoriasis usually between the ages of
3 and 6 months
Napkin psoriasis prognosis
Disappear after the age of 1 year
May be an underlying nevus, possibly an inflammatory linear verrucous epidermal nevus
Linear psoriasis
Nail changes are found in up to _____% of patients
40
Nail finding that is considered to be nearly specific for psoriasis
Oil spotting
Nail segment involved: pitting
Proximal matrix
Nail segment involved: onychorrhexis
Proximal matrix
Nail segment involved: Beau’s lines
Proximal matrix
Nail segment involved: leukonychia
Intermediate matrix
Nail segment involved: focal onycholisis
Distal matrix
Nail segment involved: thinned nail plate
Distal matrix
Nail segment involved: erythema of the lunula
Distal matrix
Nail segment involved: “oil drop” sign or “salmon patch”
Nail bed
Nail segment involved: onycholysis
Nail bed
Hyponychium
Nail segment involved: subungual hyperkeratosis
Nail bed
Hyponychium
Nail segment involved: crumbling and destruction plus other changes secondary to the specific site
Nail plate
Nail segment involved: cutaneous psoriasis
Proximal and lateral nail folds
Y/N: Alopecia is a common observation is scalp psoriasis
No - not a common observation
Present as asymptomatic erythematous patches with serpiginous borders; idiopathic inflammatory disorder resulting in the local loss of filiform papillae
Geographic tongue or
Benign migratory glossitis or
Glossitis areata migrans
Y/N: Geographic tongue is seen in many nonpsoriatic individuals
Yes
Psoriatic arthritis is seen in up to _____% of patients
40
About _____% of basal keratinocytes are cycling in normal skin, but this value rises to _____% in lesional psoriatic skin
10
100
Neutrophils exit from the tips of a subset of dermal capillaries
Squirting papillae
Accumulation of neutrophils in the overlying parakeratotic stratum corneum
Munro’s micrabscesses
Accumulation of neutrophils in the spinous layer
Spongiform pustules of Kogoj
CD8+ T cells are predominantly located in the
Epidermis
CD8+ T cells are predominantly located in the
Upper dermis
______ are prominent in developing psoriatic lesions, with _____ appearing somewhat later
Macrophages
Neutrophils
Are likely to play a major role in pustular psoriasis
Neutrophils
Psoriatic keratinocytes are engaged in an alternative pathway of keratinocyte differentiation called
Regenerative maturation
Major genetic signal for psoriasis in the MHC
HLAC*0602 - encodes HLA-Cw6 protein
Medications that exacerbate psoriasis
Antimalarials Beta blockers Lithium NSAIDs IFN- alphas and gammas Imiquimod ACE inhibitors Gemfibrozil
Elevated in up to 50% of patients and is mainly correlated with the extent of lesions and the activity of disease
Serum uric acid
Y/N: Serum uric acid is persistently elevated in patients with psoriasis.
No - usually normalize after therapy
Guttate psoriasis prognosis
Self-limited, lasting from 12-16 weeks without treatment
_____ of patients with guttate psoriasis patients later develop the chronic plaque type
One-third to two thirds
First-line therapy in mild to moderate psoriasis and in sites such as the flexures and genitalia, where other topical treatments can induce irritation
Corticosteroids
Only major concern with the use of topical vitamin D preparations
Hypercalcemia
Recommended weekly dose of vitamin D3 analogues
100 g
Naturally occurring substance found in the bark of the araroba tree in South America
Anthralin (dithranol)
Anthralin combined with UVB phototherapy
Ingram regimen
Most common side effects of anthralin
ICD
Staining of clothing, skin, hair, and nails
Nail segment involved: splinter hemorrhages
Nail bed
To prevent auto-oxidation of anthralin, ______ should be added
Salicylic acid
Main active ingredient in a tar
Carbazole
Coal tar adverse effects
Folliculitis
Unwelcome smell and appearance
Staining of clothing
Carcinogenesis
Significant proportions of patients on tazarotene develop
Local irritation
UV doses should be (decreased/increased) by at least one third if tazarotene is added to phototherapy
Decreased
Macrolide antibiotic derived from the the bacteria Streptomyces tsukubaensis
Tacrolimus
Main side effect of topical calcineurin inhibitors
Burning sensation
Carry a US FDA “black box warning” due to anecdotal reports of lymph node or skin malignancy
Tacrolimus
MOA: reduction of keratinocyte adhesion and lowering the pH of the stratum corneum, which results in reduced scaling and softening of the plaques, thereby enhancing absorption of other agents
Salicylic acid
Topical salicylic acid (decreases/increases) the efficacy of UVB phototherapy
Decreases
Peak UVB erythema appears within
24 hours of exposure
Objective in UVB phototherapy for psorisis
Minimally perceptible erythema
Excimer laser is commonly used for patients with
Stable recalcitrant plaques, particularly of the elbows and knees
Climactic therapy in psoriasis
Going to a sunny climate can improve psoriasis
MOA of methotrexate
Inhibition of AICAR (enzyme involved in purine metabolism) which leads to accumulation of extracellular adenosine
Therapeutic effects of methotrexate usually require _____ to become evident
4-8 weeks
Liver biopsy in low risk patients
Cumulative MTX dose of 3.5-4 g
Liver biopsy in patients with one or more risk factors
Baseline either before treatment or after 2-6 months of treatment
Cumulative MTX dose of 1-1.5 g
Risk factors for liver injury
Current or past alcohol consumption
Persistent abnormalities of liver function enzymes
Personal or family history of liver disease
Exposure to hepatotoxic drugs or chemicals
Diabetes mellitus
Hyperlipidemia
Obesity
Only antidote for the hematologic toxicity of MTX
Leucovorin calcium (folinic acid)
Folinic acid administration
Immediate dose of 20 mg parenterally or orally then every 6 hours
Clinical forms most responsive to etretinate or acitretin as monotherapy
Generalized pustular psoriasis
Erythrodermic psoriasis
Dose of acitretin
Initial dose of 25 mg/day, with a maintenance dose of 20-50 mg/day
Inhibitor of PDE-4 which degrades cAMP intracellularly
Apremilast
Apremilast adverse effects
GI symptoms (diarrhea, nausea, headaches) Worsening of depression
Oral Janus kinase inhibitor that has a role in downstream signaling of multiple proinflammatory cytokines
Tofacitinib
Tofacitinib is only approved for
Rheumatoid arthritis
Tofacitinib adverse effects
Changes in hemoglobin
Leukopenias
Lipid abnormalities
Increased incidences of viral infections, particularly herpes zoster
Neutral cyclic undecapeptide derived from the fungus Tolypocladium inflatum gams
Cyclosporin A
Y/N: Nephrotoxic effects of cyclosporine A are largely irreversible.
Yes
Most common adverse effects in patients using cylosporin A for short periods of time
Neurologic - tremors, headache, paresthesia, hyperesthesia
Y/N: Fumaric acid is poorly absorbed after oral intake.
Yes - Esters are used for treatment are almost completely absorbed in the small intestines
Systemic steroids may have a role in the management of
Persistent, otherwise uncontrollable, erythroderma and fulminant generalized pustular psoriasis if other drugs are ineffective
Inhibitor of inosine-5’-monophosphate dehydrogenase
Mycophenelate mofetil
Purine analog that has been highly effective for psoriasis
6-thioguanine
Antimetabolite that has been shown to be effective as monotherapy for psoriasis
Hydroxyurea
Most troublesome cutaneous reaction to hydroxyurea
Leg ulcers
Three types of biologics for psoriasis
- Recombinant human cytokines
- Fusion proteins
- Monoclonal autoantibodies- fully humanized, humanized or chimeric
TNF-alpha antagonists
Infliximab Etanercept Adalimumab Golimumab Certolizumab pegol
Chimeric monoclonal antibody that has high specificity, affinity, and avidity for TNF-alpha
Infliximab
Human recombinant, soluble, TNF-alpha receptor-Fc IgG fusion protein
Etanercept
Fully human recombinant IgG1 monoclonal antibodies and specifically targets TNF-alpha
Adalimumab
Golimumab
Polyethylene glycol Fab’ fragment of a humanized TNF inhibitor monoclonal antibody
Certolizumab pegol
Human monoclonal antibody that binds the shared p40 subunit of IL-12 and IL-23
Ustekinumab
Interleukin-17A antagonists
Secukinumab
Ixekizumab
Brodalumab
Fully human antibody that binds and neutralizes IL-17A
Secukinumab
Humanized antibody that binds and neutralizes IL-17A
Ixekizumab
Fully human antibody targeting the IL-17 receptor alpha chain
Brodalumab