108 - Benign Epithelial Tumors, Hamartomas, and Hyperplasias Flashcards
Most common acquired benign epithelial tumor of the skin
Seborrheic keratoses
Most common malignancy associated with Leser-Trelat sign
Gastrointestinal
Second most common malignancy associated with Leser-Trelat sign
Lymphoproliferative disease
Pseudo-sign of Leser-Trelat may be caused by
Chemotherapeutic agents, such as cytarabine - may cause inflammation of preexisting SKs, which then become more clinically apparent
Most frequently detected in SK are activating mutations in
FGFR3
PIK3CA
Clinicopathologic variants of SK
Common SK Reticulated SK Stucco ketatosis Melanoacanthoma DPN Polypoid SK
Histologic variants of SK
Clonal SK
Irritated SK
Malignant transformation or collision lesions
SK lesions wtih surrounding eczematous changes
Meyerson phenomenon
An association with _____ has been suggested in lichen striatus
Atopic dermatitis
The eruption of lichen striatus is self-limited, with spontaneous regression with
A few months to 2 years
In lichen striatus, there may be a dermal lymphocytic infiltrate in a perivascular and periadnexal pattern, with characterstic accentuation around
Eccrine coils
Predilection site of clear cell acanthoma
Lower legs of middle-aged to older individuals
Solitary, shiny, erythematous to brown, well-demarcater papule or nodule that blanched almost fully with pressure
Surrounding collarette of scale
Clear cel acanthoma
Clear cell acanthoma show dermoscopic features similar to
Psoriasis
Keratinocyte pallor in clear cell acanthoma is because of heavy cytoplasmic glycogen, as evidenced by _____ positivity
Periodic acid-Schiff
Chronic tender nodule thay develops most commonly on the helix of the ear in men older than 50 years of age
Chondrodermatitis nodularis helicis
Skin-colored, umbilicated papule on the head or neck of middle-aged and older individuals
Histology: cup-shaped epidermal invagination with acantholysis and dyskeratosis filled with keratinaceous plug
Warty dyskeratoma
Fissured or ulcerated, firm, fresh-colored nodule, usually retroauricular, that appears in areas of friction, as with ill-fitting eyeglasses
Acanthoma fissuratum/granuloma fissuratum
Most common variant of epidermal nevi
Keratinocytic epidermal nevus
Unilateral subtype of keratinocytic epidermal nevi
Nevus unius lateris
Bilateral subtype of keratinocytic epidermal nevi
Ichthyosis hystrix
Hairless, yellow, waxy and verrucous plaques following a blaschkoid pattern most commonly on the scalp
Nevus sebaceous
Schimmelpening syndrome is also called
Nevus sebaceous syndrome
After puberty, nevus sebaceous become (less/more) thickened and verrucous because of hormonal influences
More
Most common tumors found within nevus sebaceous
Trichoblastoma (7%) Syringocystadenoma papilliferum (5%)
The risk for developing true BCC in nevus sebaceous is currently believed to be closer to _____%
1
Nevus comedonicus syndrome is the association of nevus comedonicus with noncutaneous findings such as
Skeletal defects
Cerebral abnormalities
Cataracts
(SCC)
Most common extracutaneous anomalied associated with epidermal nevus syndrome
Ocular
Neurologic
Skeletal
Segmental smooth muscle hamartoma in association with musculoskeletal defects such as ipsilateral breast hypoplasia
Becker nevus syndrome
Epidermal hamartoma with long, fine white hair in addition to ocular, neurologic, and skeletal deficiencies
Angora hair nevus syndrome
Genetic disorders that may predispose individuals to having epidermoid cysts
Gorlin syndrome (nevoid BCC syndrome) Pachyonychia congenita type 2 (Jackson-Lawler type) Gardner syndrome
Arise from the epithelium located between the orifice of the sebaceous glabd and the arrector pili muscle
Trichilemmal cyst
Trichilemmal cysts arise from the
Outer root sheath
Steatocystoma multiplex can be found in syndromes such as
Alagille syndrome
Pachyonychia congenita type II
Lined with epitheliun containing a lymphocytic infiltrate and lymphoid follicles are common
Brachial cyst
