108 - Benign Epithelial Tumors, Hamartomas, and Hyperplasias

Question 1

Most common acquired benign epithelial tumor of the skin

Answer 1

Seborrheic keratoses

Question 2

Most common malignancy associated with Leser-Trelat sign

Answer 2

Gastrointestinal

Question 3

Second most common malignancy associated with Leser-Trelat sign

Answer 3

Lymphoproliferative disease

Question 4

Pseudo-sign of Leser-Trelat may be caused by

Answer 4

Chemotherapeutic agents, such as cytarabine - may cause inflammation of preexisting SKs, which then become more clinically apparent

Question 5

Most frequently detected in SK are activating mutations in

Answer 5

FGFR3

PIK3CA

Question 6

Clinicopathologic variants of SK

Answer 6

Common SK
Reticulated SK
Stucco ketatosis
Melanoacanthoma
DPN
Polypoid SK

Question 7

Histologic variants of SK

Answer 7

Clonal SK
Irritated SK
Malignant transformation or collision lesions

Question 8

SK lesions wtih surrounding eczematous changes

Answer 8

Meyerson phenomenon

Question 9

An association with _____ has been suggested in lichen striatus

Answer 9

Atopic dermatitis

Question 10

The eruption of lichen striatus is self-limited, with spontaneous regression with

Answer 10

A few months to 2 years

Question 11

In lichen striatus, there may be a dermal lymphocytic infiltrate in a perivascular and periadnexal pattern, with characterstic accentuation around

Answer 11

Eccrine coils

Question 12

Predilection site of clear cell acanthoma

Answer 12

Lower legs of middle-aged to older individuals

Question 13

Solitary, shiny, erythematous to brown, well-demarcater papule or nodule that blanched almost fully with pressure
Surrounding collarette of scale

Answer 13

Clear cel acanthoma

Question 14

Clear cell acanthoma show dermoscopic features similar to

Answer 14

Psoriasis

Question 15

Keratinocyte pallor in clear cell acanthoma is because of heavy cytoplasmic glycogen, as evidenced by _____ positivity

Answer 15

Periodic acid-Schiff

Question 16

Chronic tender nodule thay develops most commonly on the helix of the ear in men older than 50 years of age

Answer 16

Chondrodermatitis nodularis helicis

Question 17

Skin-colored, umbilicated papule on the head or neck of middle-aged and older individuals
Histology: cup-shaped epidermal invagination with acantholysis and dyskeratosis filled with keratinaceous plug

Answer 17

Warty dyskeratoma

Question 18

Fissured or ulcerated, firm, fresh-colored nodule, usually retroauricular, that appears in areas of friction, as with ill-fitting eyeglasses

Answer 18

Acanthoma fissuratum/granuloma fissuratum

Question 19

Most common variant of epidermal nevi

Answer 19

Keratinocytic epidermal nevus

Question 20

Unilateral subtype of keratinocytic epidermal nevi

Answer 20

Nevus unius lateris

Question 21

Bilateral subtype of keratinocytic epidermal nevi

Answer 21

Ichthyosis hystrix

Question 22

Hairless, yellow, waxy and verrucous plaques following a blaschkoid pattern most commonly on the scalp

Answer 22

Nevus sebaceous

Question 23

Schimmelpening syndrome is also called

Answer 23

Nevus sebaceous syndrome

Question 24

After puberty, nevus sebaceous become (less/more) thickened and verrucous because of hormonal influences

Answer 24

More

Question 25

Most common tumors found within nevus sebaceous

Answer 25

``` Trichoblastoma (7%) Syringocystadenoma papilliferum (5%) ```

Question 26

The risk for developing true BCC in nevus sebaceous is currently believed to be closer to _____%

Answer 26

1

Question 27

Nevus comedonicus syndrome is the association of nevus comedonicus with noncutaneous findings such as

Answer 27

Skeletal defects Cerebral abnormalities Cataracts (SCC)

Question 28

Most common extracutaneous anomalied associated with epidermal nevus syndrome

Answer 28

Ocular Neurologic Skeletal

Question 29

Segmental smooth muscle hamartoma in association with musculoskeletal defects such as ipsilateral breast hypoplasia

Answer 29

Becker nevus syndrome

Question 30

Epidermal hamartoma with long, fine white hair in addition to ocular, neurologic, and skeletal deficiencies

Answer 30

Angora hair nevus syndrome

Question 31

Genetic disorders that may predispose individuals to having epidermoid cysts

Answer 31

``` Gorlin syndrome (nevoid BCC syndrome) Pachyonychia congenita type 2 (Jackson-Lawler type) Gardner syndrome ```

Question 32

Arise from the epithelium located between the orifice of the sebaceous glabd and the arrector pili muscle

Answer 32

Trichilemmal cyst

Question 33

Trichilemmal cysts arise from the

Answer 33

Outer root sheath

Question 34

Steatocystoma multiplex can be found in syndromes such as

Answer 34

Alagille syndrome | Pachyonychia congenita type II

Question 35

Lined with epitheliun containing a lymphocytic infiltrate and lymphoid follicles are common

Answer 35

Brachial cyst