140 - Erythema Elevatum Diutinum

Question 1

EED may present at any age but is most common in the

Answer 1

Fourth though sixth decades

Question 2

EED typically first presents as edematous, erythematous to violaceous papules, nodules, and plaques, distributed symmetrically upon the

Answer 2

Skin overlying joints of the fingers, toes, and hands

Extensor surfaces, such as the elbows, wrists, knees, ankles, legs, and Achilles tendon

Question 3

A hypothesis in the pathogenesis of EED is the formation of antigen-antibody complexes leads to deposition of immune complexes in blood vessels. This leads to complement activation, with chemotaxis of neutrophils, the latter perhaps due to overexpression of

Answer 3

IL-8

Question 4

Most frequent association with EED

Answer 4

IgA paraproteinemia

Question 5

Histologic differential of EED
Red-brown to violaceous papules and plaques, often with a peau d’orange appearance
Face is the most common location

Answer 5

Granuloma faciale

Question 6

(GF/EED) is more likely to demonstrate admixed plasma cells and eosinophils, whereas (GF/EED) is more likely to demonstrate histiocytes and granulomatous areas

Answer 6

GF

EED

Question 7

Some dermatopathologists have advocated for the term _____ to represent a late-stage common endpoint of GF and EED

Answer 7

“Localized chronic fibrosing vasculitis”

Question 8

First-line agents for EED

Answer 8

Sulfone-based therapies, including dapsone and sulfapyridine

Question 9

Y/N: Chronic fibrotic lesions are unlikely to respond to any therapy

Answer 9

Yes