2.3B Infertility Continued Flashcards

1
Q

Psychosocial Support

A
  • Priority for couples seeking fertility treatment
  • Life stressor that effects self esteem, relationships, life goals and careers
  • Interventions are painful and intrusive
  • Timed abstinence can create stress
  • Financially expensive
  • Can cause distress, anger, isolation, sexual dysfunction, strain on relationship
  • Exacerbated with pre-existing anxiety or depression
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2
Q

Lifestyle Change (Non-Medical Therapy)

A
  • Hot baths and tight athletic clothes can cause too high temperature for spermatogenesis
  • Some lubricants can diminish sperm motility/quality
  • Cell phones worn by belt/hip have been linked to lower sperm quality
  • Changes in nutrition may increase fertility
  • Exercise and avoiding toxins
  • Weight normalization and maintain normal glucose
  • Timing of intercourse
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3
Q

Complementary Alternative Measures

A
- Herbal therapies not proven to work
Stress management
- Aromatherapy
- Yoga
- Meditation
- Nutritional/Exercise counseling
  • Mind/spirit/body exercises
  • Acupuncture can lower anxiety and improve pregnancy rates for women going through IVF
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4
Q

Medical Therapy for Women

A
  • Infections treated with antibiotics
  • Surgery to correct tubal blockage or pelvic distortion
  • Removal of uterine fibroids (growths)
  • Laparoscopic removal of endometrial adhesions, implants, and draining of hydrosalpinges (fluid in fallopian tubes)
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5
Q

Medical Therapy for Men

A
  • Corrected thyroid or adrenal gland issues
  • Infection treated with antibiotics
  • Surgery to correct varicoceles (enlargement of vein), blockages or tumors
  • FSH, gonadotropins, clomiphene can be used to stimulate spermatogenesis in men with hypogonadism.
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6
Q

Menotropins

A

Human menopausal gonadotropins (hMG)

- Helps with Ovarian Follicular growth and maturation

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7
Q

Human Chorionic Gonadotropin (hCG)

A
  • Induces Ovulation
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8
Q

Letrozole (off-label use)

A
  • Ovulation Induction
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9
Q

Exogenous Progesterone

A

Treatment of Luteal Phase Inadequacy

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10
Q

Metformin (off-label use)

A
  • Restores cyclic ovulation and menses in many women with PCOS
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11
Q
Clomiphene Citrate (FSH/LH) 
Ovarian Stimulant
A
  • If ovarian reserve is sufficient, this is given to women to stimulate ovary to produce follicles.
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12
Q

Assisted Reproductive Technology (ART)

A
  • Manipulation of egg, sperm, and/or embryo
    Types
  • Introducing sperm into uterus or tubules
  • Removing eggs from woman
  • Fertilizing egg in laboratory
  • Returning embryo to woman or surrogate carrier
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13
Q

Intrauterine Insemination (IUI)

A
  • Ovarian stimulation therapy followed by timed intercourse.
  • Used when sperm quality is low, cervical mucus unfavored, presence of semen allergy.
  • Preferred technique for introducing donor sperm or sperm that has been washed
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14
Q

In Vitro Fertilization - Embryo Transfer (IVF-ET)

A
  • Used when blockage or inflammation from endometriosis impairs tubal patency or when tubes are surgically removed
  • Eggs are removed with intravaginal needle aspiration.
  • Sperm is injected in
  • Fertilized egg transferred into uterus
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15
Q

Gamete Intrafallopian Transfer and Zygote Intrafallopian Transfer

A

GIFT similar to IVG-ET requires at least 1 normal uterine tube.

  • Oocytes aspirated from follicles via laparoscopy
  • Semen collected before laparoscopy
  • Ova and sperm are transferred into uterine tube permitting natural fertilization and cleavage (cell division)

ZIFT - is like GIFT but fertilization occurs In Vitro then placed in uterine tube.

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16
Q

Oocyte Donation

A

Women who have ovarian failure, oophorectomy, genetic defect, fail to achieve pregnancy with own eggs are eligible for donor eggs.
- Donation from women who are 35 or younger, healthy, recruited and paid to undergo ovarian stimulation and oocyte retrieval

17
Q

Cryopreservation

A
  • Sperm, ovarian tissue, oocytes, or embryos can be cryopreserved for later use.
18
Q

Sperm Donation

A

Therapeutic Donor Insemination
- Male partner is absent, produces unfavorable sperm, couple has genetic defect, male partner has anti-sperm antibodies, woman without male partner.

19
Q

Embryo Donation

A
  • Couples who do not want their frozen embryos release it for other infertile couples
20
Q

Surrogate Mother and Embryo Host

A
  • Surrogate mother is inseminated with semen from infertile woman’s partner and carries baby until birth. Baby is then adopted by infertile couple
  • Ovum is retrieved from infertile woman, fertilized with partner’s sperm, and placed into uterus of an embryo or gestational carrier.
21
Q

Risks of ART

A
  • Ovarian stimulation, nausea, fluid retention, ovarian hyperstimulation
  • Invasive procedures
  • Psychological Stress
  • General Anesthesia
  • Ethical and Legal ssues
22
Q

Intracytoplasmic Sperm Injection

A
  • Sperm cell injected directly into egg to achieve fertilization (Used with IVF-ET)
  • Used when male is has low sperm count, couple has genetic defect, male has anti-sperm antibodies.
23
Q

Assisted Hatching

A
  • Zona pellucida is penetrated chemically/manually to allow embryo to hatch in uterine wall. Used with IVF-ET
  • Used for recurrent miscarriages, improve implantation rate in women with previously unsuccessful IVF attempts, advanced age.
24
Q

Zygote Intrafallopian Transfer (ZIFT)

A
  • After In-vitro fertilization, ova is placed in uterine tube during zygote phase
25
Q

Therapeutic Donor Insemination

A
  • Donor sperm used to inseminate the female partner.
  • Can be used with IUI, IVF-ET, GIFT, or ZIFT
  • Male partner has low sperm count, genetic defect, anti-sperm antibodies, lesbian or transgender couple.
26
Q

Issues with Treatment to Discuss

A
  • Risk of multiple gestation
  • Possible need for multifetal reduction
  • Possible need for oocytes, sperm, or embryo’s for the female partner or gestational carrier.
  • Freezing embryo for later use
  • Possible risk of long term medication and treatment
  • Stress Management Techniques