173 - ATB (FQ + Macrolides + Aminosides + Imidazolés) Flashcards

1
Q

ATB : FQ

- Molécules / administration

A

Molécules:

  • Ofloxacine (Oflocet)
  • Ciprofloxacine (Ciflox)

Administration : x2/ PO ou IV
Poso : 200mgx2/j

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2
Q

ATB : FQ

- Spectre + résistances

A

Spectre:
BGN (E. Coli) / FQ anti-PSDP: lévofloxacine (Tavanic) / Staph méti-R / intra-cellulaire

Résistances:
streptocoques / entérocoques / anaérobies

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3
Q

ATB : FQ

- Indications

A

Indications:

  • Infections urinaires +++
  • Diarrhée bactérienne (typhoïde)
  • Ostéo-articulaire
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4
Q

ATB : FQ

- CI + ES

A

CI:

  • grossesse-allaitement
  • photo-exposition

ES:

  • tendinopathie ++
  • phototoxicité
  • Trbl digestifs - rénaux
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5
Q

ATB : Macrolides

- Molécules

A

Azithromycine (Zithromax)
Spiramcycine (Rovamycine)
Clarithromycine (Zeclar)
Erythromycine (Ery)

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6
Q

ATB : Macrolides

- Spectre + résistance

A

Spectre:

  • germes intra-cellulaires
  • toxoplasmose

Résistances:

  • BGN (E. Coli) / entérocoque
  • inconstant: staph
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7
Q

ATB : Macrolides

- Indications

A

Bactériostatique

  • Infections génitales (IST)
  • Pneumopathie atypique
  • Eradication HP
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8
Q

ATB : Macrolides

- CI + ES

A

CI: allongement du QT (TDP)

ES:

  • ototoxicité
  • allergie
  • ESM si surdosage
  • !! inhibiteurs enzymatiques
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9
Q

ATB : Aminosides

- Molécules + administration

A

Molécules

  • Gentamicine (Gentalline)
  • Amikacine (Amiklin)

Administration : x1/j IV ou IM
Poso : 3-6mg/kg

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10
Q

ATB : Aminosides

- Spectre + résistance

A

Spectre large:

  • staphylocoque
  • BGN, entérocoque
  • strepto+ anaérobies si asso β-lactamines

Résistances: rares

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11
Q

ATB : Aminosides

- Indication

A

Asso ac β-lactamine sur infections sévères

Bactéricide

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12
Q

ATB : Aminosides

- CI + ES

A

CI: myasthénie

ES:
- Ototoxicité
- Néphrotoxicité (NTI)
=> IR : adaptation poso / espacer prises / dosage résiduel

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13
Q

ATB : Imidazolés

- Molécule

A

Métronidazole (Flagyl)

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14
Q

ATB : Imidazolés

- Spectre + résistance

A

Spectre:

  • anaérobies
  • antiparasitaire (dont trichomonas)

Résistances: actinomyces / propionibacterium

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15
Q

ATB : Imidazolés

- Indications

A
  • infections dentaires
  • pneumopathies d’inhalation
  • IG
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16
Q

ATB : Imidazolés

- CI + ES

A

CI: allergie
ES: signes digestifs / effet antabuse