16c. Fertility - Microbes & Fertility Flashcards
What affect can periodontal disease have on female fertility?
Lengthen conception time by approx. 2 months
Why can periodontal disease lengthen female conception time?
Prevents ovulation
Increases inflammatory markers (IL-1)
IL-1 inhibits GnRH production
Which bacteria has been implicated in premature delivery?
Fusobacterium nucleatum
Where does the seminal microbiome originate from?
GIT
Mouth
Vagina
What are the functions of the seminal microbiome?
Aid conception
Support health of the offspring
Modulate immune responses
Which bacteria is dominant in the seminal microbiome?
Lactobacillus
(like the VMB)
What is the seminal microbiome negatively impacted by?
Antibiotics
Antifungals
STIs
Prostatitis
Lubricants
Smoking
Alcohol
Obesity
Poor penile hygiene practices
Which bacteria is implicated in male fertility?
Ureaplasma urealyticum
Which bacteria is implicated in low quality semen quality?
E. coli
Prevotella
Chlamydia
Gonorrhoea
Bacteroidetes
Why can bacteria cause low quality semen quality?
They generate oxidative stress and sperm damage
Which bacteria is dominant in the vaginal microbiome?
Lactobacillus
Why is dominant Lactobacillus good in the vaginal microbiome?
Creates an acidic, hospitable environment which prevents the overgrowth of potential pathogens
Which strain of Lactobacillus is associated with a higher implantation rate in women undergoing IVF?
Lactobacillus crispatus
Which bacteria, coupled with low Lacto, can increase the chance of miscarriage?
Ureaplasma
Gardnerella
Which VMB bacteria have been negatively associated with fertility?
Mycoplasma
Ureaplasma
Chlamydia
