11b. CV Health - Risk Factors Flashcards
What are the risk factors for CVD?
Family history
Genetics
Ethnicity
Gender
Smoking
Sedentary lifestyle
Chronic stress
Periodontal disease
Heavy metals
Dysbiosis
Poor diet
Dyslipidaemia
Hypertension
Inflammation
Obesity
Insulin resistance
Mitochondrial dysfunction
Elevated homocysteine
Thyroid hormones
Advanced glycation end products
Melatonin deficiency
How does family history pose a risk factor for CVD?
Offspring of parents = 60-75% risk increase
Siblings = 40% risk increase
SNPs on which genes pose a risk for CVD?
MTHFR
ACE
NOS3
MnSOD
Which ethnicities face an increased risk of CVD?
South Asian
Sub-Saharan African
Why does gender pose a risk to CVD?
Common view that CVD is male pathology
Mortality in women (35-54) increasing
Women experience more vague signs - lightheaded with exertion
Symptoms can be mistaken for menopause or heartburn
Why is dyslipidaemia a risk factor for CVD?
Increased total cholesterol
Increased LDL, VLDL, Lp(a)
Increased triglycerides
Reduced HDL
What diet and lifestyle factors are associated with dyslipidaemia?
Sedentary lifestyle
Excess alcohol
Smoking
Obesity
High intake of saturated/trans fats
Menopause
Which conditions increase the risk of dyslipidaemia?
T2D
Hypothyroidism
CKD
Why is mitochondrial dysfunction a risk factor for CVD?
ATP is required to pump Ca ions out of the myocardial cells
Aids relaxation
Why is elevated homocysteine a risk factor for CVD?
Associated with LDL oxidation
Monocyte adhesion
Endothelium dysfunction
What can contribute to elevated homocysteine?
Low folate
Low B12
SNPs
Why can low folate and B12 lead to elevated homocysteine?
Needed for re-methylation of homocysteine to methionine
Which SNPs can lead to elevated homocysteine?
MTHFR
MTR/MTRR
FUT2
TCN
How can a SNP on MTHFR lead to elevated homocysteine?
Impacts supply of methyl groups needed to methylate B12 in methionine cycle
How can a SNP on MTR/MTRR lead to elevated homocysteine?
Impacts B12 activation
How can a SNP on FUT2/TCN lead to elevated homocysteine?
Impacts B12 absorption
Which other genes are needed for methylating homocysteine?
PEMT/COMT (choline)
BHMT (betaine)
How can thyroid hormones be a risk factor for CVD?
TH receptors are present in the myocardium and vascular tissue
Minor TH changes can alter CV homostasis
Hypo and hyperthyroidism are linked with endothelium dysfunction, dyslipidaemia and BP changes
How does inflammation pose a risk to CVD?
Inflammation contributes to endothelium dysfunction
In turn, endothelium dysfunction, subintimal cholesterol accumulation and recruitment of monocytes and T-cells drives the inflammatory response
How does obesity pose a risk to CVD?
Excess adipose tissue perpetuates inflammation, contributing to vascular breakdown and metabolic complications
What is the vasoconstrictor peptide that inflammation is linked with?
Endothelin-1 (ET-1)