15k. Men's Health - Prostate Cancer & Prostatitis Flashcards
Signs and symptoms of prostate cancer
Same as BPH +
Haematuria
Pain on ejaculation
Back pain
Risk factors for prostate cancer
Dietary
Abdominal obesity
Poor methylation
Increased 5a-reductase
Dysbiosis
Nutrient def/insufficiencies
SNPs
What dietary factors can contribute to prostate cancer?
Processed meats
High refined sugar
Low fibre
Caffeine
High saturated/trans fats
Dairy
What causes of abdominal obesity can lead to prostate cancer?
Increased insulin resistance
Chronic inflammation
Dysregulated sex hormones
How might poor methylation come about?
Lack of key nutrients
COMT SNP
Low AO status
How might dysbiosis contribute to prostate cancer?
Dysbiosis can raise beta-glucuronidase = raised circulating oestrogens = cell proliferation
Impaired barrier = low grade inflammation
Which SNP could contribute to prostate cancer?
CYP3A4
Why can a SNP on CYP3A4 contribute to prostate cancer?
Associated with oxidative deactivation of testosterone
Natural approach to prostate cancer
Naturopathic diet with focus on Zn and Se-rich foods
Med diet
Nutrients to support prostate cancer
Se
Zn
D
Lycopene
Reishi
Shiitake
Why is Se good for prostate cancer?
Increases glutathione peroxidase
Dosage of Se to support prostate cancer
200-600mg/day
Why is Zn good for prostate cancer?
Inhibits prostate cancer cell growth
Dosage of Zn to support prostate cancer
15-30mg/day
Which nutrients can increase intestinal and prostate absorption rates?
Quercetin
Resveratrol
EGCG
Curcumin
Why is vit D good for prostate cancer?
Anti-proliferative
Why is lycopene good for prostate cancer?
Induces apoptosis
Blocks cellular gap junction responsible for cancer cell invasion
Dosage of lycopene for prostate cancer
2tbsp tomato puree/day
Why is reishi good for prostate cancer?
Triterpenes suppress migration and invasion of prostate cancer cells
Induces apoptosis
Dosage of reishi to support prostate cancer
3-9g/day
Why is shiitake good for prostate cancer?
Anti-proliferative
Anti-angiogenic
(due to beta glucan lentinan)
Dosage of shiitake to support prostate cancer
1.5-10g/day
Signs and symptoms of prostatitis
Similar to BPH+
Frequent UTIs
Dysuria
Blood in urine or semen
Urethral discharge
Pain on ejaculation
Pain around genitalia/anus/lower abdomen
Causes of prostatitis
Chronic low-grade inflammation
Low immune function
Low testosterone
Genitourinary dysbiosis
STDs
Natural approach to prostatitis
Naturopathic diet with focus on lowering inflammation
Supporting immune system
Zn/Se/Lycopene/Saw palmetto - prostate support
Quercetin - to reduce inflammation
Pro-/prebiotics to increase microbial diversity
