12g. Immune Health - SLE

Question 1

Signs and symptoms of SLE

Answer 1

Fatigue
Joint inflammation
Photosensitivity
Butterfly skin rash

Question 2

Which gender is SLE more prevalent?

Answer 2

Female

Question 3

How is SLE diagnosed?

Answer 3

Anti-nuclear antibodies (ANA)
Double-stranded DNA (dsDNA)

Question 4

Causes and risk factors for SLE

Answer 4

Genetics - HLA DR-3/2
Oestrogen dominance
Formula-fed
Infectious trigger - EBV, periodontal disease
Toxins
Stress
Low vit D

Question 5

What is the pathophysiology of SLE?

Answer 5

Tissue damage due to widespread cellular apoptosis
Defective clearance allows for antigen production
Reduced glycolysis, b-oxidation impairs energy production
Increased blood lipids, OS and inflammation
Reduced EFA, methylation, glutathione