15j. Men's Health - BPH Flashcards

1
Q

What is BPH?

A

Enlargement of the prostate without presence of malignancy

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2
Q

Who does BPH mainly affect?

A

Older men

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3
Q

Signs and symptoms of BPH

A

Urinary frequency
Urgency
Hesitancy
Nocturia
Incomplete evacuation
Terminal dribbling

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4
Q

How is BPH usually tested?

A

Digital rectal exam
PSA blood test
Ultrasound

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5
Q

Why is a PSA blood test particularly useful?

A

Raised PSA indicates possible prostate enlargement or inflammation

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6
Q

What level of PSA needs investigation?

A

Levels >4.0 ng/ml

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7
Q

What are the causes of BPH?

A

High DHT levels
Obesity
IR
Inflammation
Excess alcohol
Low Zn
High stress
Higher ratio of oestrogens to testosterone

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8
Q

Why is high stress a risk factor for BPH?

A

Increase of noradrenaline stimulates a-adrenoreceptors on prostate smooth muscle cells = smooth muscle hyperplasia

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9
Q

Why is a higher ratio of oestrogens to testosterone a risk factor for BPH?

A

Oestrogen increases prostate growth
Declining testosterone as get older can heighten the affect of oestrogens/xenoestrogens on prostate tissue

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10
Q

Natural approach to supporting BPH

A

Naturopathic diet with focus on Zn rich foods and organic
Optimise body weight
Address stress
Remove alcohol/caffeine/artificial sweeteners/fizzy drinks
Include rainbow of plant foods
Reduce excess oestrogens
Physical activity

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11
Q

Why is removing alcohol/caffeine/artificial sweeteners/fizzy drinks good for supporting BPH?

A

Can irritate the bladder making urinary symptoms worse

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12
Q

Why is having a rainbow of foods good for supporting BPH?

A

Polyphenols to inhibit 5a-reductase activity, reduce inflammation/OS

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13
Q

Examples of rainbow foods/polyphenols to support BPH

A

Lycopene - tomato paste
EGCG - green tea
Lignans - flax, sesame
Daidzein - fermented soya beans
Kaempferol - apples, broccoli, onions
Fisetin - strawberries, apples, grapes

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14
Q

How can excess oestrogens be reduced to support BPH?

A

Reduce expose to xenoestrogens
Include aromatase inhibitors (white button mushrooms)
Support phase 1 and 2 liver detox
Support bowel clearance (fibre, probiotics)

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15
Q

Why is physical activity good for supporting BPH?

A

Shown to improve nocturia

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16
Q

Nutrients to support BPH

A

Zn
Saw palmetto
Nettle
Se
D
Beta-sitosterol
Reishi
Berberine

17
Q

Why is beta-sitosterol good for BPH?

A

Improves urinary flow
Inhibits 5a-reductase
Inhibits aromatase

18
Q

Dosage of beta-sitosterol in supporting BPH

A

60-130mg/day

19
Q

Why is Se good for BPH?

A

Glutathione peroxidase synthesis
Reduced hyperplasia

20
Q

Dosage of Se in supporting BPH

A

200-600mg/day

21
Q

Why is reishi good for BPH?

A

Inhibits 5a-reductase
Reduces PSA levels

22
Q

Dosage of reishi in supporting BPH

A

3-9g/day

23
Q

Why is vit D good for supporting BPH?

A

Decreases prostate cell proliferation
Anti-inflammatory

24
Q

Why is berberine good for BPH?

A

Reduces prostate hyperplasia
Inhibits 5a-reductase

25
Q

Dosage of berberine to support BPH

A

50-250mg/day