02/28 Flashcards
What are the Antimicrobial proteins found as the Nonspecific Interior Barriers?
Interferons + Complement Proteins
Interferons are a category of
Cytokines
What are Cytokines?
Small proteins made by the body
What is the function of cytokines?
They regulate, facilitate, and help our immune system
How do Cytokines help our immune system?
- Communicate between cells like cell to cell signaling
- Control development and behavior of immune cells
- Play a role in inflammatory response
How do interferons play a role in our body’s response to an infection?
They stimulate natural killer cells to destroy virus-infected cells
What triggers the cell to produce interferons?
The entering of a virus
Interferons are released into the cell via
Exocytosis
How do interferons act in order to respond to an infection?
They function like hormones and locate receptors to bind to
What happens after an interferon binds to a receptor?
The neighboring cell then produces anti-body proteins to protect itself from virus
What is the function of complement proteins?
- They increase the likelihood of cells to be phagocytized
- Play a role in the inflammatory response
- Increase likelihood of lysis (burst)
How do complement proteins increase the likelihood of cells to be phagocytized?
They mark cells for destruction
Inflammation is a type of physiological response which
Causes redness, heat, swelling, and pain
Within inflammation, what causes for changes in blood vessels?
Chemicals released like histamine and cytokines to get body tissue to react
What happens to the arterioles in inflammation?
They will vasodilate, allowing for an increase in blood flow
The vasodilation of arterioles causes for resistance to
Decrease
What happens in capillaries during inflammation?
There is an increase in permeability and they get leaky
What happens when the capillaries experience an increase in permeability?
White blood cells leave the capillaries and go out to phagocytize any debris
Chemotaxis is the
Recruitment of leukocytes
Fevers come in response to
Different pathogens
During a fever, what does the body do?
Reset the set point
What do the immune cells do during a fever?
They secrete pyrogens
What is the function of pyrogens?
They talk to hypothalamus, which regulates body temperature
What happens in the onset stage of a fever?
There are chills
