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Plastic Surgery( Grabb)Ali jasim > Wound Healing and Management of Chronic Wounds > Flashcards

Wound Healing and Management of Chronic Wounds Flashcards

1
Q

Platelets play are the chief effector cells during hemostasis

A

T

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2
Q

Platelet release several growth factors and cytokines, such
as platelet-derived growth factor (PDGF) and transforming growth
factor-P (TGF-P)

A

T

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3
Q

Microphage are also responsible
for releasing several proangiogenic and antiangiogenic growth factors that are critical for revascularization of wounds

A

F Platelets are also responsible
for releasing several proangiogenic and antiangiogenic growth factors that are critical for revascularization of wounds

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4
Q

the inflammatory phase lasts 48 hours

A

T

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5
Q

macrophage invasion is critical to
the inflammatory phase because macrophage-defective or macrophage-depleted animals undergo .abnormal wound healing.

A

T

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6
Q

Macrophages are responsible
for releasing a whole host of mediators primarily through binding
to integrin receptors on the ECM

A

T

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7
Q

tumor necrosis factor a
and interleukin-I (IL-1)4 secreted from the microphage

A

t

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8
Q

Proliferation phase 48 hours to 10 days after tissue injury

A

T

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9
Q

Epidermal growth factors, heparin-binding epidermal growth factor (HB-EGF), and transforming growth factor-alpha (TGF-a), which are the main
members of the epidermal growth factor family involved in wound
healing

A

T

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10
Q

Fibroblasts and macrophages
replace the fibrin mesh to form granulation tissue

A

T

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11
Q

Remodeling start from2 weeks and can last for years

A

T

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12
Q

type I collagen into mainly type III collagen by matrix metalloproteinases (MMPs)

A

F type III collagen into mainly type I collagen by matrix metalloproteinases (MMPs)

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13
Q

Cutaneous scar tissue is composed of high ECM macromolecules compare to normal tissue

A

F Cutaneous scar tissue is composed of the same ECM macromolecules as normal tissue

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14
Q

Increased
levels of TGF-Pl have been implicated in hypertrophic adult scars

A

T

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15
Q

Fibroblasts are thought to generate cell traction
forces that are much greater than needed for cell migration

A

T

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16
Q

cells without mechanical stress or stimuli
adopt a spherical shape and enter cell-cycle arrest and apoptosis

A

T

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17
Q

Chronic wound any wound that last more than 1 month

A

F that persist for longer than 6 weeks.

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18
Q

Percentage of venous & arterial ulcer

A

venous insufficiency constitute
70%, arterial disease 10%, and ulcers of mixed etiology 15% of leg
ulcer presentations

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19
Q

fibrin is known to decrease collagen production

A

T

20
Q

Venous ulcer over bony prominences

A

F Arterail

21
Q

The prevalence of diabetic foot ulcers in individuals with diabetes

A

15%

22
Q

Topical antimicrobials have promoted bacterial resistance

A

T

23
Q

NPWT with instillation and adjunctive sodium hypochlorite solution
was effective at reducing both planktonic and nonplanktonic (biofilm) microorganisms

A

T

24
Q

no significant difference
in the percentage of ulcers healed when compared with placebo or
platelet-poor plasma therapy

A

T

25
Q

What is Apligraf?

A

Bovine collagen matrix incorporated with
human neonatal fibroblasts and neonatal keratinocytes to act as a
scaffold as well as providing cells that produce growth factors and
ECM components

26
Q

Dermagraft comprises a polyglactin scaffold with dermal neonatal fibroblasts.

A

T

27
Q

Epicel

A

cultured epithelial autografts using patients’ own keratinocytes,

28
Q

what is Integra ?

A

Integra™ (Integra LifeSciences) is a bilayer
matrix of bovine collagen and glycosaminoglycan derived from shark
skin that is lyophilized to form a highly porous scaffold

29
Q

Allopatch

A

which is a decellularized scaffold derived from human cadaveric
tissue, has demonstrated efficacy in closure of nonhealing diabetic
foot ulcers

30
Q

Grafix

A

Is a cryopreserved placental membrane, have shown to significantly improve diabetic foot ulcer healing and reduce related complications

31
Q

fetal wound healing during the first two trimesters differs from the normal wound healing process

A

T Scarless healing

32
Q

After 48 hours the macrophage becomes the dominant cell type. In contrast
to neutrophil, this is critical to wound healing because it orchestrates growth factors such as TGF-beta, which
promotes collagen production

A

T

33
Q

During remodeling phase, net
collagen production is static

A

T

34
Q

PDGF promotes fibroblast,
endothelial cell, and smooth muscle proliferation rather than keratinocyte proliferation

A

T

35
Q

Hypertrophic scars have
an equal sex ratio, are typically seen in younger age groups

A

T

36
Q

Keloid scars are only seen in humans

A

T

37
Q

east harmful for imaging of the limp vascular diseas is CTA

A

F Magnetic resonance angiography (MRA)

38
Q

A normal anklebrachial pressure index is between 0.9 and 1.2 greater than 1.2 suggests calcification A value of less than 0.5
suggests critical arterial stenosis

A

T

39
Q

Osteoradionecrosis (ORN) is a condition where bone death occurs secondary to radiation and is most commonly
seen in the mandible following treatment of head and neck cancers best trerated with HPO

A

T

40
Q

Apligraf

A

comprises a bilayer of bovine collagen
and human foreskin-derived fibroblast matrix under human foreskin-derived keratinocytes use in diabetic foot and
venous leg ulcers

41
Q

The hypoxic environment increases expression of hypoxia-inducible
factor 1 (HIF-la) protein to serve as the primary stimulus of angiogenesis

A

T

42
Q

Granulation tissue, also known as new stroma, consists of new connective tissue
(specifically hyaluronic acid, procollagen, elastin, and proteoglycan)
and blood vessels

A

T

43
Q

Fibroblasts are also injured and
contribute to the late effects of radiation injury such as fibrosis and
contraction

A

T

44
Q

Systemic antibiotics are beneficial in infected chronic wounds but
are not indicated for most chronic wounds that are merely colonized
with bacteria

A

T

45
Q

obesity is related to lower levels of lymphocyte proliferate, altered cytokine levels and peripheral immune function which improves upon weight loss

A

T

Plastic Surgery( Grabb)Ali jasim (92 decks)

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