Head and Neck Cancer and Salivary Gland Tumors Flashcards
About 80% ofsalivary gland tumors occur in the parotid
glands
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only about l % occur in the sublingual glands.
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About 80% of parotid gland tumors are benign
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50% of submandibular gland
tumors and 80% of minor salivary gland tumors are
malignant
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Risk of3.4 for oral cavity and 6.8 for
oropharynx SCC in current tobacco smokers compared with nonsmokers
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HPV-11, are associated with the development of malignancy in the
oropharynx as well as ofthe cervix and anogenital tract
F HPV-16, are associated with the development of malignancy in the
oropharynx as well as ofthe cervix and anogenital tract
Pleomorphic Adenoma are most common in the fourth to
fifth decade.
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5% of pleomorphic adenomas
may undergo malignant transformation
F 15% of pleomorphic adenomas
may undergo malignant transformation
Warthin Tumor is the
second most common tumor of the parotid gland and is benign
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Warthin tumors predominantly occur in males of 50 to 70 years of
age, most frequently smokers
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are the most common unilateral
salivary gland tumors (5%-14%)
F is the most common bilateral
salivary gland tumors (5%-14%)
Warthin can diagnose by PET scan
F. Warthin tumors do not infrequently
demonstrate fluorodeoxyglucose uptake on PET scan, potentially
leading to a false-positive study
Mucoepidermoid Carcinoma is the most common salivary gland malignancy (about 35% of
salivary gland cancers
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Low- and intermediate-grade tumors often present
as asymptomatic slow-growing, solitary masses
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Overall survival is 80%
to 90% for low- and intermediate-grade tumors
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Elective node dissection is often recommended for all -grade tumors
F Elective
node dissection is often recommended for high-grade tumors
Acinic cell carcinoma accounts for 8% to 14% of salivary gland cancers
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Adenoid cystic carcinoma (ACC) is the second most common malignancy ofthesalivaryglands
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Pleomorphic adenoma, also known as benign mixed tumor
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Pleomorphic adenomas are well circumscribed and are
grossly lobular and gray in appearance
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This tumor is histologically characterized by epithelial
and connective tissue elements, with stellate and spindle cells interspersed within a myxoid background (Pleomorphic adenoma)
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Pleomorphic adenomas are treated by surgical excision and are
associated with very low recurrence rates (0%-5%)
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Adenoid Cystic Carcinoma are three histologic subtypes: cribriform, tubular,
and solid.
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The cribriform pattern has a classic Swiss cheese appearance
with cells arranged in nests separated by round or oval spaces
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The tubular pattern has a glandular architecture, whereas the solid (or basaloid)
pattern has sheets ofcells with little or no luminal spaces
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