Management of Scars

Question 1

Keloids: rarely spontaneously regress

Answer 1

T

Question 2

Keloids familial predisposition
common

Answer 2

T

Question 3

TGF-beta excess contributes to fibroproliferative scar formation (keloids and hypertrophic scar)

Answer 3

T

Question 4

mature scar, which has approximately 80% of the tensile strength of normal unwounded skin, occurs
between 6 and 18 months after wounding

Answer 4

T

Question 5

Keliod result from relatively minor injury or insult

Answer 5

T

Question 6

Partial or total resolution or regression can spontaneously
occur IN Hypertrophic scars

Answer 6

T

Question 7

Decreased collagen content and production in hypertrophic scar

Answer 7

T

Question 8

massage
can aid in the flattening and softening ofscars and limiting some scar
contractures

Answer 8

T

Question 9

Professional
massage therapists appear to be of benefit in scarring related to burn

Answer 9

T

Question 10

The Mechanism of action Silicone Gel appears to be that oftemperature increase, or by
any chemical effects of absorbed silicone

Answer 10

F appears to be the occlusive nature of silicone dressing and epithelial hydration

Question 11

Compression garments are recommended prophylactically in burn injury after
extensive skin grafting and/or if spontaneous wound healing
requires longer than 10 to 14 days

Answer 11

T

Question 12

Pressure requirements is mandatory for pressure garment work

Answer 12

F Pressure requirements for effectiveness have not been established

Question 13

although 15 to 25 mm Hg is the
target pressure reported

Answer 13

t

Question 14

Effectiveness of pressure in keloid may be
up to 80% following complete surgical excision

Answer 14

T

Question 15

Steroid pretreatment
for keloids followed by surgical excision and follow-up postoperative
injections produce reported cure rates of up to 80%

Answer 15

T

Question 16

Keloid excision
followed by radiation therapy within 24 to 48 hours either as a
single dose or as multiple doses can reduce recurrence and lead
to cure rates between 67% and 98%

Answer 16

T

Question 17

MOA OF radiation in keloid

Answer 17

Radiation damages keloid fibroblasts, affecting collagen production and structure

Question 18

Radiation monotherapy is not
effective

Answer 18

T

Question 19

Concern for malignancy due to radiation
therapy is advisable, especially in the pediatric age patient or in
areas prone to radiation-induced carcinomas, such as thyroid and
breast

Answer 19

T

Question 20

Radiation therapy for refractory/intractable hypertrophic scarring has been reported as effective

Answer 20

T

Question 21

soft tissue fibrosis
as encountered with higher doses of radiation therapy is common

Answer 21

F soft tissue fibrosis
as encountered with higher doses of radiation therapy is not likely

Question 22

Topical cryotherapy may achieve initial positive results in hypertrophic scars and keloid treatment; subsequent recurrence rates are
high

Answer 22

T

Question 23

intraoperative injection of botulinum
toxin type A, 10 U/cm in a split-scar randomized trial improves surgically
incisional scars

Answer 23

T

Question 24

mechanism of action of botulinum toxin

Answer 24

is inhibition of TGF-beta
1 and cell cycle interaction, diminishing fibroblast cell functions/
regulation

Question 25

Vitamin E and onion extract have littleclinical evidence in scar management

Answer 25

T

Question 26

Hypertrophic scars, treated early with laser , less
than I-year while still erythematous, responded better than those of
more mature age

Answer 26

T

Question 27

Increased number of mast cells in hypertrophic scar

Answer 27

T

Question 28

Recommendation for treatment is to wear the silicone gel dressing for 12 to 24 hours per day for
2 to 3 months at the onset of visible scar abnormality

Answer 28

T

Question 29

Treatments for scar prevention as well
as established hypertrophic scar therapy indicated response rates in
the range of 70% with PDL laser

Answer 29

T

Question 30

There is growing
subjective evidence to suggest that fat grafting may become a mainstay for scar treatment

Answer 30

T