Wk5 Small Intestine and Colon Path pt 2

Question 1

Polyps associated with UC and Crohn’s:

Answer 1

Inflammatory

Question 2

Most common polyp in young children:

Answer 2

Hamartomatous

Question 3

Polyp usually seen in the rectum

children

Answer 3

Sporadic Juvenile polyp

aka

mucus retention polyp

Question 4

SMAD4

BMPRIA

Answer 4

juvenile polyposis syndrome

**increased risk for GI carcinomas

Question 5

STK11

mucocutaneous hyperpigmentation

hamartomatous polyps

arborizing SM pattern, pedunculated

increased CA risk

Answer 5

Peutz-Jeghers syndrome

Question 6

PTEN

trichilemmomas

acral keratoses

oral papillomas

breast lesions

macrocephaly

Answer 6

Cowden syndrome

Question 7

rare hamartomatous polyposis

unknown etiology

alopecia

cutaneous hyperpigmentation

nail atrophy/splitting

Answer 7

Cronkhite-Canada syndrome

Question 8

**Most common adult colonic polyp:

serration of mid portion of glands

Answer 8

Hyperplastic

Question 9

Neoplastic polyp

dysplastic GLANDULAR proliferation

precursor to adenocarcinoma

prophylactically removed to prevent progression to CA

Answer 9

Adenoma

adenomatous polyp

Question 10

resemble hyperplastic polyps

lack adenomatous epithilium

often found n right colon

precursor to adenocarcinoma

Answer 10

Sessile serrated polyp

Question 11

Two polyps concernig for progression to adenocarcinoma:

Answer 11

1. Adenoma

2. Sessile serrated

Question 12

APC mutation

autosomal dominant

large # of polyps in youth = 100% risk of colorectal adenocarcinoma

pigmented retinal epithelium on opthalmic exam

Answer 12

FAP

familial adenomatous polyposis

Question 13

FAP +

desmoid tumors

osteomas

epidermal cysts

dental abnormalities

thyroid tumors

Answer 13

Gardener’s syndrome

Question 14

hereditary colon CA syndrome +

CNS tumors

Answer 14

Turcot syndrome

Question 15

Turcot syndrom with APC mutation

Answer 15

medulloblastoma

Question 16

Turcot syndrome with HNPCC mutation

Answer 16

glioblastoma multiforme

Question 17

HNPCC?

Answer 17

DNA mismatch repair gene

Question 18

Dx criteria for FAP:

Answer 18

greater than 100 adenomatous polyps

Question 19

HNPCC mutation

Answer 19

Hereditary non-polyposis colorectal cancer

Lynch syndrome

Question 20

Most common malignancy of the GI tract:

Answer 20

colorectal adenocarcinoma

Question 21

Risk factors for colorectal adenocarcinoma:

Answer 21

low fiber diet high in refined carbs and fat

cigarettes

obesity

EtOH

inactivity

family hx

IBD

Question 22

napkin ring lesion

Answer 22

left sided colorectal adenocarcinoma

obstruction risk

Question 23

iron deficiency anemia in older adult is what until proven otherwise:

Answer 23

GI tract cancer

Question 24

Most common tumor of the appendix:

Answer 24

neuroendocrine

Question 25

polypoid anal wart HPV associated

Answer 25

Condyloma accuminatum

Question 26

most common anal carcinoma HPV 16/18

Answer 26

squamous cell carcinoma

Question 27

Most common location for small intestine CA:

Answer 27

ampulla of Vater

Question 28

Most common site for SI neuroendocrine tumor:

Answer 28

jejunum/ileum

Question 29

Most common tumor of the appendix:

Answer 29

neuroendocrine

Question 30

Most common and most important risk factor for anal carcinoma:

Answer 30

HPV

Question 31

Anal Intraepithelial Neoplasia:

Answer 31

various degrees of premalignant squamous dysplasia of the anal canal **associated with HPV

Question 32

What malignancy causes pseudomyxoma peritonei?

Answer 32

appendiceal mucinous tumors

Question 33

Lymphomatosis polyposis:

Answer 33

GIST tumor Mantle cell lymphoma

Question 34

Melanosis coli:

Answer 34

associated with anthraceneline laxatives

Question 35

Risk factors for small bowel adenocarcinoma:

Answer 35

FAP Crohn's Celiac