Wk5 Liver Path pt3 Flashcards
Most common benign neoplasm of the liver
Hemangioma
Congenital dilation of the common bile duct
Choledochal cyst
proliferation of all liver parenchymal elements
not malignant
**fibrous scar with stellate configuration
Focal Nodular Hyperplasia
Diffuse, nonfibrosing nodular hyperplasia of the liver
associated with compromised intrahepatic bloodflow
Nodular regenerative hyperplasia
Well-circumscribed benign neoplasm
well differentiated hepatocytes
young women
oral contraceptives
anabolic steroids
Hepatocellular adenoma
grossly: multiple small white nodules
micro: disordered ectatic bile ducts in fibrous stroma
mimics metastatic carcinoma
Bile duct hamartoma
Solitary benign proliferation of bile ducts
looks similar to metastatic carcinoma
Bile duct adenoma
Most common malignant tumors found in liver
metastases from elsewhere
lung, GI, breast, pancreas are most common
Typical American presenting with Hepatocellular carcinoma
over age 60
younger where HBV is endemic
Most common risks for HCC
chronic viral hepatitis
toxins
**cirrhosis
soft and hemorrhagic tumor
HCC
When to suspect HCC
any cirrhotic patient suffering SUDDEN clinical deterioration
**sx may be masked by underlying liver disease
alpha-fetoprotein > 200 ng/ml
HCC
HCC that occurs predominantly in young adults with cirrhosis or hepatitis
Fibrolamellar Variant of HCC
white and hard tumor nodules in the liver
Intrahepatic Cholangiocarcinoma