Wk1 Protein and Lipids Flashcards
Pepsinogen –> ____?____ –> Pepsin
H+
Trypsinogen > ? > Trypsin
Enteropepsidase
Chymotrypsinogen > ? > Chymotrypsin
trypsin
Proelastase > ? > Elastase
trypsin
Procarboxypeptidases > ? > carboxypeptidases
trypsin
Exo vs Endo peptidases?
Exo – cleave bonds on the end of peptide chains
Endo – cleave bonds within peptide chains
Why do CF patients have trouble absorbing protein?
Blockage of pancreatic duct
How do AA get from lumen into cells?
Na+ symporter
**Na conc gradient generated by Na/K ATPase
How do AAs get from epithelial cells into blood?
Facilitated transport
Transporter for tryptophan
Bo aka SLC6A9
What happens if pt is SLC6A9 deficient?
Hartnup disease
What are the three hallmark sx of Hartnup disease?
- Dementia
- Dermatitis
- Diarrhea
Hartnup disease causes pellagra d/t lack of production of what?
niacin
without SLC6A9 can’t absorb tryptophan to synthesize niacin
Niacin is an important component of which molecules:
NADH
NADPH
Mutation of SLC7A9 (Bo+) or causes?
cystinuria
**loss of basic AA (Arg, Lys, His)
What does cystinuria cause?
kidney stones
Two transporter mutation that cause cystinuria?
- SLC7A9 (Bo+)
2. SLC3A1 (rBAT)
Route for AA absorption but not important for majority of dietary AA uptake?
rx with glutathione via gama-glutamyl transpepsidase
4 fates of AAs once they are in the cell:
- Protein synth
- N-containing compounds
- Urea cycle
- C for TCA cycle