Wk4 viral gastroenteritis Flashcards by Weston Tardy

Q

DS RNA (class III)

Icosahedral

nonenveloped

segmented

A

Rotavirus

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Q

Infects mature absorptive villous epithelium in upper 2/3 of small intestine

A

rotavirus

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Q

How does rotavirus spread?

A

fecal-oral

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Q

Cytolytic toxin-like action

loss of electrolytes –> diarrhea

A

rotavirus

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Q

Typically not seen until after 6 months of age

most serious under age 2

asymptomatic in adults

A

rotavirus

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Q

Contagious period for rotavirus?

A

2-5 days after start of diarrhea phase

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Q

daycare centers

preschools

hospitalized infants

A

rotavirus

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Q

highest incidence of rotavirus infx

A

fall, winter, spring

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Q

test for rota virus

A

ELISA of stool

electron microscopy

RT-PCR (distinguishes between genotypes)

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Q

Virus with ISVP activated by stomach

A

rotavirus

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Q

NSP4

A

rotavirus toxin

forms pore in ER membrane

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Q

review rotavirus vaccines

A

slide 14

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Q

Ddx if suspecting rotavirus?

A

Norovirus

Adenovirus

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Q

Most common foodborne virus

A

Norovirus

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Q

SS (+) RNA (class IV)

Icosahedral

Nonsegmented

Nonenveloped

Calciviridae

A

Norovirus

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Q

Causes “outbreaks” of gastroenteritis?

A

norovirus

Q

Course of norovirus infx:

A

resolves within 48 hours

Q

Mutates quickly

new strains every few years

A

norovirus

Q

leading cause of gastroenteritis in the US

A

norovirus

Q

Test for norovirus

A

RT-PCR

Q

Ddx if suspecting norovirus:

A

Bacillus cirrus

**rice associated

**onset is usually hours vs about 1 day with norovirus

Q

How does norovirus cause diarrhea?

A

cytolitic

Q

DS DNA linear (class I)

Nonenveloped

Icosahedral

A

Adenovirus