Wk3 Iron and Copper

Question 1

Where is creatine synthesized?

Answer 1

kidney (ornithine) –> liver (methylated by SAM)

Question 2

What is creatines role in muscle and brain?

Answer 2

Buffer of high energy phosphate bonds for ADP/ATP

Question 3

Path of Fe absorption in the brush border?

Answer 3

Fe3+ reduced to Fe2+ by brush border reductase

Fe2++ to cell via DMT1

excess Fe2+ to blood via ferroportin

Oxidized by hephaestin(HE)/ceruloplasmin
**requires Copper

Question 4

Hepcidin?

Answer 4

produced by liver in high Fe state to inhibit ferroportin

Question 5

Vit that enhances Fe absorption:

Answer 5

Vit C

Question 6

Iron inhibits ____ absorption.

Answer 6

zinc

Question 7

Blood smear of Fe deficiency:

Answer 7

microcytic anemia

Question 8

Cu’s path to blood?

Answer 8

reduced by same brush border reductase as iron

enters cell through CTR1

enters blood via ATP7A

Question 9

Mutation in ATP7A? (copper can’t get to blood)

hypothermia

hypotonia

seizures

FTT

Answer 9

Menkes kinky hair syndrome

Question 10

Aside from ceruloplasmin, what is copper used for?

Answer 10

Cytochrome C oxidase

lysyl oxidase (collagen synthesis)

superoxide dismutase

catacholamine synthesis (dopamine B-hydroxylase)

Question 11

Fe + ? aid electron transport?

Answer 11

Sulfur

Question 12

Mutation in liver specific copper transporter ATP7B?

Answer 12

Wilson disease

Question 13

Kayser-Fleischer ring (in iris)

Answer 13

Wilson disease

high copper