Wk4 GI Immunity

Question 1

Cell responsible for immune tolerance of novel substances that may be important for nutrition:

Answer 1

T reg’s

Question 2

4 layers of GI defense:

Answer 2

1. intraepithelial
2. lamina propria
3. Peyer’s patch
4. Mesenteric lymph nodes

Question 3

aEB7 integrin

Answer 3

Intraepithelial lymphocyte chemotactic factor in vili

associated with E-cadherin

upper GI

Question 4

Intraepithelial lymphocyte of upper GI vili?

Answer 4

CD8+

Question 5

MADCAM1 (a selectin)

Answer 5

Upper GI

lamina propria chemotactic factor

associated with a4B7 integrin

Question 6

Peyers patch location:

Answer 6

lower GI

Question 7

Main regulator of inflammatory response:

Answer 7

NKkB

Question 8

Slide 19

Answer 8

lymphoid tissue

Question 9

IL for T regs?

Answer 9

IL-10

Question 10

lower GI cell that engulfs stuff:

Answer 10

M cell

Question 11

Adaptive immunity “training” location for ingested antigens:

Answer 11

Peyer’s Patches

Mesenteric LN’s

lower GI

Effector cells can enter circulation and distribute throughout the body

Question 12

Seven defense strategies of GI sys:

Answer 12

1. Block entry into organism (most pathogens)
2. Block entry into cell (bacteria, viruses)
3. Prohibit spreading (most pathogens)
4. Direct killing (most pathogens)
5. Kill infected host cell (virus, intracellular bacteria, protozoa)
6. expulsion (multicellular parasites)
7. Nutrient depravations (bacteria, protozoa)

Question 13

Methods for blocking entry into organism:

Answer 13

tight junctions

cilia

mucin

Neutralizing antibodies

Anti-microbial peptides

Enzymes (lysozyme, PLA2 from paneth cells)

Question 14

Methods for blocking entry into cell:

Answer 14

AB’s bind pathogen – prevent adherence

Bacteria agglutinate

Question 15

Methods to prohibit spreading:

Answer 15

coagulation/vasoconstriction

neutralizing Ab’s

INFa/B (type 1)

• increased MHC class 1
• increased cell mediated cytotoxicity

Question 16

Methods for direct killing:

Answer 16

anti microbial peptides

bacterial permiability increasing proteins

lysozymes and stomach environment

complement

ROSs

RNSs (reactive nitrogen species)

Question 17

Cells producing a-defensins:

Answer 17

Neuts, NKs, Paneth

Question 18

Cells producing B-defensins:

Answer 18

Leukocytes, epithelial cells

Question 19

Method for killing infected host cell:

Answer 19

INFa/B (type 1)
-induces MHC1

NKs

NK T cells

Cytotoxic T-lymphs

Antibody dependent cellular cytotoxicity (ADCC)

Question 20

Methods for expulsion:

Answer 20

IgE

Vasoactive substances
-leukotrienes, PGs, histamines

Mucous

SM contraction

cilia

Question 21

Methods for nutrient depravation:

Answer 21

Fe removed by lactoferrin

Manganese removed by NRAMP

Zinc removed by ZIP/ZnT

Question 22

Dendrites that reach out and sample lumen?

Answer 22

CD19 - ?

Question 23

Pro inflammatory cytokines?

Answer 23

INF-gama

TNF-a

IL-12

Question 24

anti-inflammatory cytokines?

Answer 24

IL-10 (T regs)

IL-1ra

Question 25

Type of inflammation with:

Th1
IFN-gama
M1 (angry) mac's
IgG, sIgA
CTL's
NKs

Answer 25

acute

Question 26

Type of inflammation with:

Th2/Th17
IL-4, IL-17
M2 mac's
IgE
Eosinophils
Basophils

Answer 26

Chronic

Question 27

try to figure out slide 63

Answer 27

it’s on the test