Wk4 GI Immunity Flashcards
Cell responsible for immune tolerance of novel substances that may be important for nutrition:
T reg’s
4 layers of GI defense:
- intraepithelial
- lamina propria
- Peyer’s patch
- Mesenteric lymph nodes
aEB7 integrin
Intraepithelial lymphocyte chemotactic factor in vili
associated with E-cadherin
upper GI
Intraepithelial lymphocyte of upper GI vili?
CD8+
MADCAM1 (a selectin)
Upper GI
lamina propria chemotactic factor
associated with a4B7 integrin
Peyers patch location:
lower GI
Main regulator of inflammatory response:
NKkB
Slide 19
lymphoid tissue
IL for T regs?
IL-10
lower GI cell that engulfs stuff:
M cell
Adaptive immunity “training” location for ingested antigens:
Peyer’s Patches
Mesenteric LN’s
lower GI
Effector cells can enter circulation and distribute throughout the body
Seven defense strategies of GI sys:
- Block entry into organism (most pathogens)
- Block entry into cell (bacteria, viruses)
- Prohibit spreading (most pathogens)
- Direct killing (most pathogens)
- Kill infected host cell (virus, intracellular bacteria, protozoa)
- expulsion (multicellular parasites)
- Nutrient depravations (bacteria, protozoa)
Methods for blocking entry into organism:
tight junctions
cilia
mucin
Neutralizing antibodies
Anti-microbial peptides
Enzymes (lysozyme, PLA2 from paneth cells)
Methods for blocking entry into cell:
AB’s bind pathogen – prevent adherence
Bacteria agglutinate
Methods to prohibit spreading:
coagulation/vasoconstriction
neutralizing Ab’s
INFa/B (type 1)
- increased MHC class 1
- increased cell mediated cytotoxicity
Methods for direct killing:
anti microbial peptides
bacterial permiability increasing proteins
lysozymes and stomach environment
complement
ROSs
RNSs (reactive nitrogen species)
Cells producing a-defensins:
Neuts, NKs, Paneth
Cells producing B-defensins:
Leukocytes, epithelial cells
Method for killing infected host cell:
INFa/B (type 1)
-induces MHC1
NKs
NK T cells
Cytotoxic T-lymphs
Antibody dependent cellular cytotoxicity (ADCC)
Methods for expulsion:
IgE
Vasoactive substances
-leukotrienes, PGs, histamines
Mucous
SM contraction
cilia
Methods for nutrient depravation:
Fe removed by lactoferrin
Manganese removed by NRAMP
Zinc removed by ZIP/ZnT
Dendrites that reach out and sample lumen?
CD19 - ?
Pro inflammatory cytokines?
INF-gama
TNF-a
IL-12
anti-inflammatory cytokines?
IL-10 (T regs)
IL-1ra
Type of inflammation with:
Th1 IFN-gama M1 (angry) mac's IgG, sIgA CTL's NKs
acute
Type of inflammation with:
Th2/Th17 IL-4, IL-17 M2 mac's IgE Eosinophils Basophils
Chronic
try to figure out slide 63
it’s on the test
