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GI > Wk4 Anti-emetics > Flashcards

Wk4 Anti-emetics Flashcards

1
Q

Binds toxin in upper GI

acute tx of poisoning

A

activated charcoal

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2
Q

Induces vomiting

no longer used

A

Ipecac

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3
Q

Lower GI

cathartic

decontaminating agent

A

polyethylene glycol solution

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4
Q

Best tx for chemo nausea

given before chemo

5HT3 inhibitors

A

-setrons

dolasetron
granisetron
ondansetron (zofran)
palonosetron

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5
Q

Three H1 antagonists

cause sedation

A

Dimenhydrinate

Diphenhydramine

Meclizine

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6
Q

Anticholinergic

some D2 antagonism also

best for motion sickness

acts on cerebellum

transdermal to decrease side fx

A

scopolamine

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7
Q

Two NK1 antagonists (substance P)

chemo N/V

given with 5HT3’s + dex

CYP3A4 can interact with some chemo drugs

A

APREPITANT

fosAPREPITANT

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8
Q

D2 antagonists (5)

cause sedation

A

droperidole

metaclopramide

prochlorperazine

promethazine

thiethylperazine

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9
Q

Two corticosteroids

MOA: unknown in nausea

given with 5HT3s and NK1s in chemo

A

dexamethazone

methylpredisolone

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10
Q

act on central cannabinoid receptors

A

dronabinol

nabilone

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11
Q

Dolasetron

Granisetron

Ondansetron

Palonosetron

A

5HT3 antagonists

act mostly in GI

some vomiting center and chemoreceptor activity
-“redundancy”

Best given BEFORE chemo

Acute phase – first 24 hrs

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12
Q

Dimenhydrinate

A

H1 antagonist

causes sedation

**maybe some anticholinergic

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13
Q

Diphenhydramine

A

H1 antagonist

causes sedation

**maybe some anticholinergic

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14
Q

Meclizine

A

H1 antagonist

causes sedation

**maybe some anticholinergic

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15
Q

Scopolamine

A

Anticholinergic

Motion sickness

cerebellum

some D2 action

transdermal patch decreases side fx

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16
Q

Aprepitan

Fosaprepitan

A

NK1 (substance P) antagonists

chemo N/V

given with 5HT3’s and dex

CYP3A4 –> chemo interactions

17
Q

Droperidol

A

D2 antagonist

sedation

18
Q

Metoclopramide

A

D2 antagonist

sedation

19
Q

Prochlorperazine

A

D2 antagonist

sedation

20
Q

Promethazine

A

D2 antagonist

sedation

21
Q

Thiethylperazine

A

D2 antagonist

sedation

22
Q

Dronabinol

A

canniboid receptors

23
Q

Nabilone

A

canniboid receptors

24
Q

Important antiemetic receptors in cerebellum:

A

muscarinics

H1’s

25
Q

Important antiemetic receptors in Solitary tract nucleus

A

muscarinic

H1

also have 5HT3 and D2

26
Q

Important receptors in higher centers:

A

NK1

cannabinoid

27
Q

Important receptor in vomiting center

A

muscarinic

also have:

5HT3

D2

28
Q

Important receptors in chemoreceptive trigger zone:

A

5HT3

D2

opiod

also have:

M1

H1

GI (46 decks)

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