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GI > Wk2 Gastric secretion > Flashcards

Wk2 Gastric secretion Flashcards

1
Q

Location of parietal cells:

A

body of stomach

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2
Q

Cell type in gastric pit:

A

simple columnar

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3
Q

cells that make up gastric gland:

A

parietal

mucous

chief

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4
Q

Cell type and location where gastrin is secreted from:

A

G cells

antrum

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5
Q

Gastrin receptors in which cells?

Where are they found?

A

parietal (stimulates acid secretion)

body (corpus) / fundus

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6
Q

Mechanism for gastrin secretion from seeing food?

A

vagus –> Gastrin-releasing peptide –> GRP receptor in G cell

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7
Q

Three molecules that stimulate acid secretion from parietal cells:

A

gastrin

histamine

Ach

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8
Q

Histamine pathway for H+ secretion:

A

cAMP dependent pathway

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9
Q

Ach pathway for H+ secretion:

A

M3 receptor –> Ca2+ release

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10
Q

Gastrin pathway for H+ secretion:

A

CCK2 receptor –> Ca2+ release

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11
Q

Parietal cell pump that secretes acid?

A

H+ / K+ ATPase

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12
Q

Cells that release histamine:

What triggers it?

A

ECL cells

gastrin from blood

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13
Q

Look at slide

A

13

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14
Q

Describe “alkaline tide”:

A

HCO3- leaves basolateral parietal cell via Cl- / HCO3- exchanger and goes into blood

**HCO3- can also leave via vesicular fusion

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15
Q

Inhibitor of gastrin release:

A

somatostatin

**released when pH is less than 3

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16
Q

What is the effect of eating on somatostatin release?

A

raises gastric pH, decreasing somatostatin release

17
Q

Where is somatostatin released from?

A

D cells

antrum

18
Q

3 acid decreasing roles of somatostatin:

A
  1. inhibits G cell release of gastrin
  2. inhibits cAMP in parietal cells
  3. Inhibits ECL secretion of histamine
19
Q

What else (besides somatostatin) can inhibit cAMP in parietal cells?

A

Prostaglandins

20
Q

What is intrinsic factor?

A

glycoprotein secreted by parietal cells that mediates uptake of B12 in ilium

**not inhibited by PPIs

21
Q

Cells where pepsinogen is secreted?

A

Chief cells

22
Q

What mediates pepsinogen secretion?

A

Stim by Ach and gastrin

Inhib by secretin

23
Q

What else (besides pepsinogen) is secreted by Chief cells?

A

gastric lipase

24
Q

Stimulates mucous secretion by mucous cells:

25
Q

Suppresses mucosal bicarb?

A

catecholamines (stress ulcers)

26
Q

Helps repair disrupted epithelium?

A

trefoil factors

27
Q

gastrin secreting tumor in pancreas?

A

Zollinger-Ellison syndrome (gastrinoma)

28
Q

Reduced acid secretion:

A

Achlorhydria

29
Q

IF source:

A

parietal cell

30
Q

Pepsinogen function:

A

protein digestion

31
Q

Gastroferrin source:

A

parietal cells

32
Q

Gastroferrin function:

A

Fe++ (ferrous) absorption

GI (46 decks)

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