Vitamin C Flashcards
What are the characteristics of Water Soluble Vitamins?
- Soluble in water
- Simple diffusion (large amount)
- Through a carrier-mediated process (smaller amounts)
- Distributed in aqueous phases of the cell
Ascorbic Acid
VITAMIN C
Vitamin C Nomenclature:
◦Antiascorbutic vitamin
◦“fresh food” vitamin
Biologically active forms of vitamin C
◦L-ascorbic acid
◦L-dehydroascorbic acid
Vitamin C is Most easily destroyed by:
heat, alkali, light, oxygen; Fe & Cu)
Cannot be synthesized by human
gulonolactone oxidase
Vitamin C is absorbed in the ______
Absorbed in GI
Vitamin C is not stored in the _____
Tissues
Highest amount of Vitamin C is found in the ____
liver, adrenal glands, and glandular organs
what is the vitamin C that transport and store in the plasma?
ascorbic acid in free form
what is the vitamin C that transport and store in the cell?
glucose transporter & active transport system and moves it into to the cell as dehydroascorbic acid where it is readily reduced as ascorbic acid
Vitamin C when excreted in the urine
dehydroascorbate,
ketogulonate,
ascorbate-2-sulfate
oxalic acid
how many g/day is excreted as ascorbic acid
2 g/day
FUNCTIONS OF VITAMIN C
- Antioxidant properties
- Formation & maintenance of intercellular cementing substances
- Wound healing & fracture healing
- Collagen Synthesis
- Promotes resistance to infection
translocates fatty acid from the cytosol to the mitochondria needed for fatty acid oxidation
Vit C needed to convert carnitine from trimethyllysine
Carnitine
A Peptide which act as hormones and hormone-releasing factors: oxytocin, cholecystokinin, gastrin
Amidated hormones
Food Sources
◦Plant: Fresh fruits (anonas, bayabas, datiles,cashew, strawberry, melon, papaya, camichile, citrus fruits, mangoes), broccoli, red bell pepper, tomatoes and GLV
◦Animal: kidney and heart
Catecholamine Hormones
epinephrine and norephinephrine
DEFICIENCY OF VITAMIN C
Scurvy
◦Legs in “frog’s position”
◦Flexing as a response to tender, painful, and swollen thighs, delayed dentition, and skeletal growth
Infantile scurvy
Effects of Excessive Intakes
- Gastrointestinal disturbances and diarrhea
- Increased possibility of forming renal oxalate and uric stones
- Can give a false positive urinary glucose test (Db test)
Vitamin C promotes this mineral absorption
Fe
Fe inhibits this mineral’s abbsorption
Cu
Vitamin C Prevents binding of ___ to ____ in intestinal cells
Cu
metallothione