Folic Acid or Pteroylglutamic acid Flashcards
what are the two functionally different membrane transport system that is involved in the cellular uptake of folate.
- reduced folate carrier
- membrane folate receptor
an essential factor for the de novo biosynthesis of purines and one pyrimidine nucleotide required for DNA synthesis
Folate
Folate is critical for he synthesis of _______
S-adenosylmethionine
a methyl donor for a variety of biologically important acceptors
S-adenosylmethionine
A dietary deficiency of folate leads to an elevation of ____ _____ concentrations, which is an early risk factor for _______
plasma homocysteine
atherosclerosis
A poor maternal folate status in early pregnancy is related to the occurrence of _____ ____ defects in the fetus.
neural tube defects
_________ in genes encoding key enzymes in folate and homocysteine metabolism play a role in _____ _____ ______ and ____ _____ defects.
Polymorphisms
occlusive vascular disease
neural tube defects
Folate deficiency has the potential to cause DNA strands breaks and DNA hypomethylation, both of which may lead to mutations and cancer.
True or false
True
Generic descriptor of ______________ and its derivative compounds
Pteroylmonoglutamic acid (folic acid) PGA
Metabolically active form
FH4 (tetrahydrofolic acid)
a carrier of single carbon moieties
FH4 (tetrahydrofolic acid)
In nature: occurs as
dihydrofolateand tetrahydrofolate
Folic originated from ___ word
Latin
Folic meaning in Latic
Leaf or Folium
Reduced form of Folic acid
Folacin
Oxidized form of folic acid
Folinic Acid
two form of food folate are:
free and conjugated
folic acid converts histidine to _______.
glutamate
folic acid Synthesize of _______ from methionine
homocysteine
folic acid is needed for methyl transfer of _____ and _____
methionine
choline
The ____ _____ is involved in a reaction which serves as a precursor for DNA synthesis
folate coenzyme
- synthesis of complex molecules from simple molecules such as sugars or amino acids, as opposed to recycling after partial degradation.
- Could affect rapidly multiplying cells ( RBC, WBC, epithelial cells of stomach, small intestines, vagina and uterine cervix)
De novo synthesis of DNA
ingestion of ___ mcg folic acid per day is recommended for all women capable of becoming pregnant.
400 mcg
Effects of Deficient Intakes
Associated with increased risk of CVD (homocysteine), neural tube defects and megaloblastic anemia
