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Ntrnl Bchmstry > Food and Drug Interaction > Flashcards

Food and Drug Interaction Flashcards

1
Q

LR,a 67 yo , man, who has had depression was prescribed an MAOI (Monoamine Oxidase inhibitors) the following foods are avoided except

  • Avocado
  • bean curd
  • bologna
  • green tea
A

Green tea

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2
Q

QUESTION : Patients taking COUMADIN, are advised not too increase or decrease their usual consumption in foods high in Vitamin K such as:

  • broccoli
  • brussels sprouts
  • green tea
  • all of the above
A

All of the above

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3
Q

TRUE or FALSE : Allupurinol is prescribed for patients
with hyperuricemia, the appropriate diet to recommend is LOW
PROTEIN DIET

A

False

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4
Q

Allupurinol is prescribed for patients

with hyperuricemia, the appropriate diet to recommend is to AVOID LOW PROTEIN DIET why?

A

AVOID LOW PROTEIN DIET. DO NOT
DRASTICALLY REDUCE DIETARY
PROTEIN INTAKE WHILE ON
ALLUPURINOL THERAPY.

A low protein diet will promote elevated
ALLUPURINOL levels.

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5
Q

FLUOROQUINOLONES(Ciprobay,Tequin, Levofloxacin)
must not be taken with the ff: foods except :
• A. Caffeine
• B. Yogurt
• C. Papaya
• D. Dairy products

A

• C. Papaya

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6
Q

REASON: FLUOROQUINOLONES(Ciprobay,Tequin, Levofloxacin)

must not be taken with the ff: foods except : PAPAYA

A 
Calcium Rich foods like YOGURT, 
DAIRY PRODUCTS , and CAFFEINE 
(even Calcium, Mg , or Fe supplements) 
BIND TO FORM INSOLUBLE 
COMPLEXES.
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7
Q

refers to the effect of a medication on food or

a nutrient in food

A

DRUG - NUTRIENT INTERACTION

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8
Q

a broad term that includes drug nutrient
interactions and the effect of a medication
on nutritional status

A

FOOD DRUG INTERACTION

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9
Q

MEDICAL TEAM MEMBERS should be
aware that therapeutically important food
and drug interaction can do the ff:

A
  1. alter the intended response to
    the medication
  2. cause drug toxicity
  3. alter normal nutritional status
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10
Q

JCIA

A

Joint Commission for International Accreditation

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11
Q

parameter for Joint Commission for International Accreditation

A

• “PATIENTS ARE EDUCATED HOW TO USE
MEDICATION……….”
• One Parameter- Patient and Family must be
educated about FOOD- DRUG interactions

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12
Q

2 BROAD TYPES OF FOOD DRUG INTERACTIONS

A

PHARMACODYNAMICS

PHARMACOKINETICS

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13
Q

PHARMACOKINETICS

A

Affects the movement of

the drug

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14
Q

PHARMACODYNAMICS

A

Pharmacologic action

of the drug

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15
Q

Benefits of Minimizing Food Drug

Interactions

A
  • Optimal nutritional status is preserved
  • Accidents and injuries are avoided
  • Disease complications are minimized
  • The cost of health care services is reduced
  • There is less professional liability
  • Licensing agency requirements are met
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16
Q

• Thought to be a HYPERSENSITIVITY

complex affecting the skin and mucous membrane

A

Stevens Johnson Syndrome

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17
Q

Drugs known to interact with grapefruit juice:

A
  • Anti-hypertensives
  • Immunosuppressants
  • Antihistamines
  • Protease inhibitors
  • Lipid-Lowering Drugs
  • Anti-anxiety, antidepressants
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18
Q

Anti-hypertensives

A 
filodipine, 
nifedipine, 
nimodipine, 
nicardipine, 
isradipine
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19
Q

Immunosuppressants

A

cyclosporine, tacrolimus

20
Q

Antihistamines

A

astemizole

21
Q

Protease inhibitors

A

saquinavir

22
Q

Lipid-Lowering Drugs

A

atorvastatin, lovastatin,

simvastatin

23
Q

Anti-anxiety, antidepressants

A 
buspirone, 
diazepam, midazolam, 
triazolam, zaleplon, 
carbamazepine, 
clomipramine, trazodone
24
Q

MAOI

A

Monoamine oxidase inhibitors (MAOI)

25
Q

Monoamine oxidase inhibitors (MAOI) interact with what pressor agents in foods

A

(tyramine, dopamine, histamine)

26
Q

_______ are generally deaminated rapidly by MAO;

A

Pressors

27
Q

MAOIs prevent the breakdown of _____ and other

pressors

A

tyramine

28
Q

Significant intake of high-______ foods (aged
cheeses, cured meats) by pts on MAOIs can
precipitate _______ crisis

A

tyramine

hypertensive

29
Q

When foods containing TYRAMINE are consumed:

“ CHEESE SYNDROME “

A

individual may suffer from hypertensive crisis

30
Q

When foods containing TYRAMINE are consumed: HYPERSEROTONIMIA –

A

if foods containing

TRYPTOPHAN are consumed

31
Q 
The following foods are high in TYRAMINE 
except :
a. Salami, Bologna
b. Sauerkraut 
c. Kosher salt 
d. Miso soup
A

c. Kosher salt

32
Q

A VASO CONSTRICTOR THAT RAISES BLOOD PRESSURE.

May trigger MIGRAINE ATTACKS

A

TYRAMINE

33
Q

FOOD SOURCES of TYRAMINE

A
  • Aged Cheese
  • Processed Meats i.e. Salami, Pepperoni
  • Red wine , Beer
  • White wine 4 to 8 oz per day only
  • Processed soup i.e. Miso soup
  • Yeast extract
34
Q

• Increases adverse effects of stimulants such as
amphetamines, methylphenidate,
theophylline, causing nervousness, tremor,
insomnia
• Counters the antianxiety effect of tranquilizers

A

Caffeine

35
Q

The following foods have CAFFEINE , which
among the following foods have the highest
caffeine content ?
a. Instant coffee
b. Brewed coffee , drip
c. Mountain Dew
d. Brewed coffee, percolator

A

b. Brewed coffee , drip

36
Q

Foods that – increases ADVERSE EFFECTS OF

STIMULANTS

A

Caffeine in foods or beverages

37
Q

an (anticoagulant) acts by preventing the

conversion of vitamin K to a usable form

A

Warfarin

38
Q

Ingestion of vitamin ___ in usable form will allow
production of more clotting factors, making warfarin
less effective

A

K

39
Q

Other foods with anticlotting qualities may also have

an effect with warfarin (garlic, onions, vitamin E in large amounts, and ginseng) TRUE or FALSE

A

True

40
Q 
• C.G. , 67 year old male , admitted at the 
Telemetry Unit , diagnosed with atrial 
fibrillation complications
• Was prescribed a COUMADIN DIET 
• How will you counsel this patient?
A

For patients taking COUMADIN( Warfarin)
• Do not increase or decrease usual consumption in
foods high in VITAMIN K
such as:
➢ broccoli , cauliflower , kale, lettuce ,cabbage
spinach, turnip greens
➢ soy containing products ,soybean oil
➢ green tea
➢ brussel sprouts , onions-fried or boiled
➢ Beef liver

41
Q

DIAZEPAM

A

VALIUM

42
Q

BARBITURATE

A

PHENOBARBITAL

43
Q

ETHANOL

A

HEPATOXIC EFFECTS

44
Q

Food or nutrients can alter the intended

pharmacologic action of a medication by ____and by _____

A

by ENHANCING by OPPOSING

45
Q

Drug effects on Nutrition: Metabolism
Phenobarbital
Phenytoin

A

Increase metabolism of Vitamin D

Vitamin K and Folic Acid

46
Q

Drug effects on Nutrition: Metabolism

Carbamazepine

A

Affect metabolism of Biotin ,
Vitamin D, and folic acid
May lead to possible depletion

Ntrnl Bchmstry (31 decks)

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