Niacin or Vitamin B3

Question 1

NIACIN is also called

Answer 1

Anti-Pellagra Factor

Question 2

Niacin is the ____ ____ water soluble vitamin

Answer 2

Most stable

heat stable

Question 3

Forms of niacin

Answer 3

◦Niacin or nicotinic acid
◦Acid form
◦Niacinamide or nicotinamide
◦Amide form

Question 4

Measurement: ◦60 mg dietary tryptophan =

Answer 4

1mg niacin

Question 5

Active coenzyme forms

Answer 5

◦Nicotinamide adenine dinucleotide(NAD or Coenzyme I)

◦Nicotinamide adenine dinucleotide phosphate(NADP or Coenzyme II)

Question 6

Functions of niacin

Answer 6

Acceptor of proton and electron:
◦Facilitates energy metabolism (aerobic and anaerobic oxidation of glucose)
◦Needed for fatty acid synthesis and oxidation
◦Needed for protein synthesis and catabolism

Question 7

Niacin intake and food sources

Answer 7

Converted from tryptophan
Mushrooms
Enriched grains
Beef, chicken, turkey, fish
liver, glandular organs

Question 8

Niacin Antagonist

Answer 8

• INH (isoniazid)
• isonicotinic and acid hydrazide (INH)
• 3-acetylpyridine

Question 9

Niacin that are biologically active

Answer 9

• niacin or nicotinic acid

- amide form: niacinamide or nicotinamide

Question 10

Nicotinic acid pharmacologic effects

Answer 10

-decreases triglycerides and increasing HDL

Question 11

Early signs of niacin deficiency

Answer 11

• anorexia
• lassitude
• indigestion
• skin changes

Question 12

Niacin deficiency

Answer 12

Pellagra

Question 13

Pellagra is characterized by 4 D’s

Answer 13

• dermatitis
• dementia
• diarrhea
• death

Question 14

a dse that is characterized by a blackish or dark scaly patches that appear symmetrically in areas exposed to sunlight.

Answer 14

bilateral dermatitis

Question 15

symptoms of niacin deficiency

Answer 15

◦Glossitis

◦Angular stomatitis (cracked corners of the mouth)

Question 16

NIACIN TOXICITY Symptoms

Answer 16

Niacin flush(painful flush and rash)
◦Dilated capillaries and causes a tingling sensation that is painful
◦Hypermotility
◦Acidity of stomach
◦Liver damage
◦Paralysis of respiratory center
NFP

Question 17

____ is poor source of niacin and tryptophan

Answer 17

Corn