Pyridoxine or Vitamin B6

Question 1

three form of pyridoxine

Answer 1

• pyridoxol
• pyridoxal
• pyridoamine

Question 2

alcohol form of pyridoxine

Answer 2

pyridoxol

Question 3

aldehyde form of pyridoxine

Answer 3

pyridoxal

Question 4

amine form of pyridoxine

Answer 4

pyridoxamine

Question 5

all three forms of pyrodoxine are converted to the active co-enzyme factor _____ _____

Answer 5

pyridoxal phosphate

Question 6

Food Sources

Answer 6

Widely distributed in foods; unstable in heat processing
◦High: meats, whole grain (wheat), liver, wheat bran, yeast extracts, vegetables and nuts
◦Others: beans, carrots, orange juice, broccoli
◦Animal sources (PLP) have higher bioavailability than plant sources (PN)

Question 7

Functions

Answer 7

◦Deamination, transamination, decarboxylation, transulphuration and desulphuration
◦Synthesis of protein*, neurotransmitters, lipids

Question 8

PLP/ NIacin: Metabolic conversion of tryptophan to _____

Answer 8

niacin

Question 9

PLP/ Niacin Release of glucose from ______

Answer 9

glycogen

Question 10

PLP/ Nervous system integrity:

Answer 10

sphingolipid (nerve cell insulator)

Question 11

PLP/ Niacin Synthesis of _______ precursor

Answer 11

acetycholine

Question 12

PLP/ Niacin Catalyzes _____ production

Answer 12

urea

Question 13

PLP/ Niacin: Modulates of _____ hormone receptors

Answer 13

steroid

Question 14

Deficiency

Answer 14

No deficiency has been observed in adult

Question 15

Effects of Deficient Intakes: adult

Answer 15

◦weakness, sleeplessness, peripheral neuropathies, cheiolosis, glossitis, stomatitis , gingivitis, and impaired cell-mediated immunity

Question 16

Effects of Deficient Intakes: infant

Answer 16

Milk-based formula with niacin (destroyed in processing):
◦Infants: irritability, poor growth, anemia and convulsions
◦Recovers upon injection of the vitamin

Question 17

Effects of Excessive Intakes

Answer 17

◦neuropathy manifesting as changes in gait and peripheral sensation overdosing is potentially dangerous

Question 18

Rats: massive doses

Answer 18

3 g/kg BW

Question 19

Humans: excessive dosage

Answer 19

50 mg/day for 6 months

Question 20

Effects of Excessive Intakes

Answer 20

◦neuropathy manifesting as changes in gait and peripheral sensation overdosing is potentially dangerous