Vibrio Cholera causes for diarrhea.

Question 1

How does Vibrio Cholera cause diarrhea?

Answer 1

Vibrio cholera causes gray, turbid stool (rice water)🡪cholera toxin functions by activating adenylyl cyclase, which increases cAMP

Question 2

How does the fimbriae of Vibrio cholerae function?

Answer 2

Fimbriae of Vibrio cholerae allow the bacteria to attach to (but do not invade) the intestinal mucosa and establish infection

Question 3

How does the cholera toxin (choleragen) of Vibrio cholerae function?

Answer 3

Cholera toxin (choleragen) of Vibrio cholerae permanently activates Gs🡪causes overactivation of adenylate cyclase in epithelial cells of the intestine → elevated cAMP, increased sodium and chloride efflux → profuse watery diarrhea