Common noninfectious causes of granulomas

Question 1

What are immune mediated noninfectious causes of granulomas?

Answer 1

Immune mediated:
-Sarcoidosis

• Crohn’s disease
• Primary biliary cholangitis (of bile tract)
• Subacute de quervain/granulomatous thyroiditis

Question 2

Which types of Vasculitis are noninfectious causes of granulomas?

Answer 2

Vasculitis:
-Granulomatosis with polyangiitis/Wegneer

• Eosinophilic granulomatosis with polyangiitis/Churg-Strauss
• Giant cell/temporal arteritis
• Takaysu arteritis

Question 3

Which types of foreign body materials are noninfectious causes of granulomas?

Answer 3

Foreign body material:
-Berylliois (beryllium)

• Talcosis
• Hypersensitivity pneumonitis (bird fancier’s disease)
• Chronic granulomatous disease (CGD=NADPH oxidase deficiency—pt’s have defective respiratory burst; increased infections with catalase-positive bacteria and fungi)