Bullous pemphigoid and pemphigus vulgaris

Question 1

What is Bullous pemphigoid vs pemphigus vulgaris? What cell connection affected?

Answer 1

Pemphigus vulgaris—autoantibodies against desmosomes—causes intraepidermal acantholysis w/ loss of the desomsome intercellular cconnections between keratinocytes; flaccid bullae/blisters

Bullous pemphigoid—autoantibodies against deeper hemidesmosomes, so keratinocyte epithelium separates from basement membrane; tense blisters