Pro-inflammatory cytokines

Question 1

Which cytokines are pro-inflammatory?

Answer 1

-IL-1 (activates endothelium to express adhesion molecules, so immune cells can migrate), Il-2, IL-6, IL-8;

• TNF-alpha—secreted by macrophages; stimulates macrophages, recruits neutrophils, and causes lymphocyte proliferation
• –TNF-alpha inhibitors=Infliximab, Adalimumab
• IFN-gamma
• PGE2 (pain)
• Endogenous pyrogens: IL-1, IL-6, TNF-alpha and PGE2
• –IL-1 and TNF-a released by macrophages🡪they increase COX activity in hypothalamus🡪hypothalamus releases PGE2🡪increased temp set point