Skin cancer

Question 1

What is a skin tumor with black-tan pigmentation; pleomorphic hyperchromatic cells within clear islands that coalescence throughout dermis and extend into papillary dermis?

Answer 1

Melanoma

• —ABCDE’s with D=diameter>6 mm
• —Melanocytes are at stratum basale of epidermis
• —In pt’s with BRAF V600 E mutation, consider Vemurafenib=BRAF kinase inhibitor