Vancomycin Flashcards
vancomycin replaced by what drug
anti-staph penicillins
what is the mechanism of action for Vancomysin
- inhibits biosynthesis of peptidoglycan during cell wall synthesis
- complexes with D-alanyl-D-alanine precursor
is vancomysin -cidal or -static
cidal
on the time and concentration graph what does vancomysin exhibit
post anti-biotic effect
how well is vancomysin absorbed in the GI tract
poorly
when is vancomycin given orally and IV
oral: C.diff
IV: systemic infections
where and under what circumstances is vancomycin distributed
mostly everywhere
-CSF only with inflammation
how is vancomycin excreted
unchanged via glomerular filteration
controversial discussion for higher trough range have what indications in the patient
endocarditis
osteomyelitis
meningitis
what is the desired peak for vancomycin
20-40 mcg/ml
what is the desired trough for vancomycin
10-20 mcg/ml
what happens when the troughs for vancomycin are too high
nephrotoxicity
what happens when the peaks are too high for vancomycin
Otoxicity
what is an adverse effect for vancomycin
Red-Man-Syndrome
- histamine like reaction
- infuse van too quickly
what bacteria does vancomycin cover
Staph a. Staph. epidermis MRSA Strep Enterococcus clostridium
