Mupriocin, Colistin, Fosfomycin, Tigecycline, Daptomycin, Telavancin,

Question 1

how is mupirocin administrated

Answer 1

topical treatment

Question 2

what does mupirocin (bactorban) treat

Answer 2

MRSA colonization eradication from Nares

Question 3

what does Colistin cover

Answer 3

SPACE bug

Question 4

what are some adverse effects for Colistin

Answer 4

nephrotoxicity

neurotoxicity

Question 5

Colistin is resistant to what bugs

Answer 5

PEK

Question 6

how is Colistin administered

Answer 6

IV
inhaled
intrathecal

Question 7

fosfomycin (monrol) is used only for what

Answer 7

UTI’s

Question 8

How many times a day do you take fosfomycin

Answer 8

1

Question 9

Tigecycline (tygacil) is what kind of drug

Answer 9

static

Question 10

what type of infections is Tigecycline used for

Answer 10

intra-abdominal infection

community acquired penumonia

Question 11

does Tigacycline treat bacterimia ? whyso?

Answer 11

no, does not attain high serum concentrations, easily diffuses into tissue

Question 12

what is the unique coverage for tigacycline

Answer 12

MRSA/VRE
gram (-)
acinetobacter
anaerobes

Question 13

As a doctor in what situation would you perscribe Tigacycline

Answer 13

3rd tier drug,

try 2 other drugs before prescribing

Question 14

Daptomycin is what kind of drug

Answer 14

cidal

Question 15

what does Daptomycin not cover and why

Answer 15

pneumonia, inactivated by pulmonary surfactant

Question 16

what does Daptomycin cover

Answer 16

Gram (+) MRSA, VRE
skin and soft tissue infections
right sided endocarditis

Question 17

Telavancin can have cross sensitivity with other drug

Answer 17

Vancomycin

Question 18

what are adverse effects for Telavancin

Answer 18

red man syndrome
prolonged QT
nephrotoxicity

Question 19

what does Telavancin cover

Answer 19

skin and soft tissue infections

gram (+), MRSA

Question 20

Do questions at end of powerpoint

Answer 20

OKay

Question 21

all sulfaonamides are similar to what other structure

Answer 21

PABA

Question 22

what is PABA a precursor for

Answer 22

synthesis of folic acid in bacteria

Question 23

Mechanism of action for sulfaonamides

Answer 23

sulfonamides compete with PABA

Question 24

what type of drug is sulfaonamides

Answer 24

static

Question 25

what is excretion for sulfonamides

Answer 25

glomerular filteration

Question 26

what is sulfonamides commonly treat

Answer 26

acute uncomplicated UTI

Question 27

what are adverse effects of sulfonamides

Answer 27

nephrotoxicity | Kernicterus

Question 28

what is kernicterus

Answer 28

decreases fetal blood levels of unconjugated bilirubin

Question 29

should you give sulfonamides to pregnant ladies

Answer 29

no

Question 30

what do sulfonamides cover

Answer 30

``` staph strep PEK H. flu salmonella shigella chlamydia trachomatis ```

Question 31

what is the mechanism of resistance for sulfonamides

Answer 31

- overproduction of PABA | - decreased permeability of bacteria to the drug

Question 32

Trimethoprin mechanisms of action

Answer 32

inhibits dihydrofolate reductase

Question 33

what type of drug is trimethoprin

Answer 33

static or cidal depending on growth condition

Question 34

why is trimethoprim more toxic than sulfonamides?

Answer 34

interacts with a system also found in humans unlike sulfonamides

Question 35

how is trimethoprim excreted

Answer 35

80% unchanged via glomerular filtration | tubular secretion

Question 36

when do you not give trimethoprim

Answer 36

``` don't use with patients who are alcoholics pregnant women debilitated patients malabsroptive syndromes ```

Question 37

what does trimethoprim treat

Answer 37

acute uncomplicated UTI recurrent UTI prophylaxis traveler's diarrhea

Question 38

what is bactrim

Answer 38

trimethoprim and sulfamethoxazole

Question 39

when do you use Bactrim

Answer 39

``` UTI RTI GI infections STDs stenotrophomonas maltophilia ```

Question 40

Bactrim interacts with what other drugs

Answer 40

Warfin | Methotexate

Question 41

What is the mechanism of action for Nitrofurantoin

Answer 41

unclear

Question 42

where is Nitrofurantoin mostly distributed

Answer 42

urine

Question 43

what are adverse effects of nitrofurantion

Answer 43

peripheral neuropathy | gastriointestinal reactions

Question 44

what are pulmonary adverse effects of nitrofurantoin

Answer 44

hypersensitivity depending on how long on tdurg

Question 45

what do nitrofurantion treat

Answer 45

acute uncomplicated UTI | UTI prophylaxis

Question 46

what is the mechansism of actin for methenamine

Answer 46

- no antibacterial effect alone | - hydrolyzed to formaldehyde which kills bacteria in acidic conditions

Question 47

what is the bioavailability for methenamine

Answer 47

excellent

Question 48

you should avoid using methenamine in what patients

Answer 48

hepatic insufficiency | renal failure

Question 49

methenamine concentrations in urine are affected by what

Answer 49

hydrolysis of meth to formaldehyde | rate of urine loss from bladder

Question 50

what does methenamine used to treat

Answer 50

UTI prophylaxis ONLY