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POD Exam 2 > Mupriocin, Colistin, Fosfomycin, Tigecycline, Daptomycin, Telavancin, > Flashcards

Mupriocin, Colistin, Fosfomycin, Tigecycline, Daptomycin, Telavancin, Flashcards

1
Q

how is mupirocin administrated

A

topical treatment

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2
Q

what does mupirocin (bactorban) treat

A

MRSA colonization eradication from Nares

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3
Q

what does Colistin cover

A

SPACE bug

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4
Q

what are some adverse effects for Colistin

A

nephrotoxicity

neurotoxicity

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5
Q

Colistin is resistant to what bugs

A

PEK

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6
Q

how is Colistin administered

A

IV
inhaled
intrathecal

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7
Q

fosfomycin (monrol) is used only for what

A

UTI’s

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8
Q

How many times a day do you take fosfomycin

A

1

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9
Q

Tigecycline (tygacil) is what kind of drug

A

static

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10
Q

what type of infections is Tigecycline used for

A

intra-abdominal infection

community acquired penumonia

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11
Q

does Tigacycline treat bacterimia ? whyso?

A

no, does not attain high serum concentrations, easily diffuses into tissue

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12
Q

what is the unique coverage for tigacycline

A

MRSA/VRE
gram (-)
acinetobacter
anaerobes

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13
Q

As a doctor in what situation would you perscribe Tigacycline

A

3rd tier drug,

try 2 other drugs before prescribing

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14
Q

Daptomycin is what kind of drug

A

cidal

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15
Q

what does Daptomycin not cover and why

A

pneumonia, inactivated by pulmonary surfactant

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16
Q

what does Daptomycin cover

A

Gram (+) MRSA, VRE
skin and soft tissue infections
right sided endocarditis

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17
Q

Telavancin can have cross sensitivity with other drug

A

Vancomycin

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18
Q

what are adverse effects for Telavancin

A

red man syndrome
prolonged QT
nephrotoxicity

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19
Q

what does Telavancin cover

A

skin and soft tissue infections

gram (+), MRSA

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20
Q

Do questions at end of powerpoint

A

OKay

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21
Q

all sulfaonamides are similar to what other structure

A

PABA

22
Q

what is PABA a precursor for

A

synthesis of folic acid in bacteria

23
Q

Mechanism of action for sulfaonamides

A

sulfonamides compete with PABA

24
Q

what type of drug is sulfaonamides

A

static

25
Q

what is excretion for sulfonamides

A

glomerular filteration

26
Q

what is sulfonamides commonly treat

A

acute uncomplicated UTI

27
Q

what are adverse effects of sulfonamides

A

nephrotoxicity

Kernicterus

28
Q

what is kernicterus

A

decreases fetal blood levels of unconjugated bilirubin

29
Q

should you give sulfonamides to pregnant ladies

A

no

30
Q

what do sulfonamides cover

A 
staph strep
PEK 
H. flu
salmonella
shigella
chlamydia trachomatis
31
Q

what is the mechanism of resistance for sulfonamides

A
  • overproduction of PABA

- decreased permeability of bacteria to the drug

32
Q

Trimethoprin mechanisms of action

A

inhibits dihydrofolate reductase

33
Q

what type of drug is trimethoprin

A

static or cidal depending on growth condition

34
Q

why is trimethoprim more toxic than sulfonamides?

A

interacts with a system also found in humans unlike sulfonamides

35
Q

how is trimethoprim excreted

A

80% unchanged via glomerular filtration

tubular secretion

36
Q

when do you not give trimethoprim

A 
don't use with patients who are 
alcoholics
pregnant women
debilitated patients
malabsroptive syndromes
37
Q

what does trimethoprim treat

A

acute uncomplicated UTI
recurrent UTI prophylaxis
traveler’s diarrhea

38
Q

what is bactrim

A

trimethoprim and sulfamethoxazole

39
Q

when do you use Bactrim

A 
UTI
RTI
GI infections
STDs
stenotrophomonas maltophilia
40
Q

Bactrim interacts with what other drugs

A

Warfin

Methotexate

41
Q

What is the mechanism of action for Nitrofurantoin

A

unclear

42
Q

where is Nitrofurantoin mostly distributed

A

urine

43
Q

what are adverse effects of nitrofurantion

A

peripheral neuropathy

gastriointestinal reactions

44
Q

what are pulmonary adverse effects of nitrofurantoin

A

hypersensitivity depending on how long on tdurg

45
Q

what do nitrofurantion treat

A

acute uncomplicated UTI

UTI prophylaxis

46
Q

what is the mechansism of actin for methenamine

A
  • no antibacterial effect alone

- hydrolyzed to formaldehyde which kills bacteria in acidic conditions

47
Q

what is the bioavailability for methenamine

A

excellent

48
Q

you should avoid using methenamine in what patients

A

hepatic insufficiency

renal failure

49
Q

methenamine concentrations in urine are affected by what

A

hydrolysis of meth to formaldehyde

rate of urine loss from bladder

50
Q

what does methenamine used to treat

A

UTI prophylaxis ONLY

POD Exam 2 (28 decks)

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