Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

POD Exam 2 > macrolides > Flashcards

macrolides Flashcards

1
Q

what is the mechanism of action for macrolides

A

reversibly binds to 50S-ribosomal subunit of bacteria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what type of drug is macrlides

A

static

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

name 3 macrolides

A

clarithromycin
Azithromycin
erythromycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what macrolide should you not give to a pregnant women

A

emycin estolate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is distribution for macrolides

A

in tissues longer than blood

-lung

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

how are macrolides excreted

A

biliary

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is the half life for azithromycin

A

long

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what are adverse effects of Erythromycin

A

GI abdominal cramps
thrombophelibitis
cholestic hepatitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what are adverse effects of clarithromycin and azithromycin

A

GI

headache

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is a durg interaction with erythromycin/clarithromycin

A

inactivates complexes with p-450 enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what do macrolides cover

A

staph strep

atypicals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what does clarithromycin and azithromycin cover that erthromycin doesnt

A

H. flu

M. Cat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

when are macrolides used

A

mycoplasma pneominia
legionnaires disease
chlamydia trachomatis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is the mechanism of action for clindamycin

A

binding of 50S ribosome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is the bioavailbilty for clindamycin

A

good

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what bacteria does clindomcin cover

A

step staph
anaerobes
toxoplasmosis

17
Q

what are adverse effects for clindomycin

A

hepatotxicity

c. diff

18
Q

Chloramphenicol mechanism of action

A

binds larger 50S subunit of 70S ribosome

19
Q

what is Chloramphenicol coverage

A

good, even CSF

20
Q

what is the best administration for Chloramphenicol

A

oral

needs to be hydrolyzed in stomach

21
Q

where is Chloramphenicol metabolized

A

liver, must watch serum levels

22
Q

what bacteria does Chloramphenicol cover

A

gram +/-
aerobic and anaerobic
rickettisa
chlamdydia

23
Q

what are adverse effects of Chloramphenicol

A

anemia
aplastic anemia
gray baby syndrome

24
Q

what is gray baby syndrome

A

toxicity involved inhibition of mitochondrial protein synthesis

25
Q

what does Chloramphenicol treat

A

bacterial meningitis

Rickettsial infections

POD Exam 2 (28 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions